| Abstract:ObjectiveTo investigate the physiological characteristics and the association with low prevalence of hypertension in “desert people”, as an isolated population, in Taklimakan Desert.MethodsAll data were obtained from each person by questionnaire and standardized physical examinations. Total 469 subjects received examinations, including 359 subjects of “desert people” (M/F=205/154), aged from 15~99 years; 101 subjects of Uyghur from Yutian county (M/F=51/50), aged from 20~85 years, as controls. Some parameters : TC, TG, LDL-C, HDL-C, Apo-A, Apo-B, Lp-a, BUN, UA and CRE were determined. The statistical analysis was performed with SAS9.1.3 Version (Inititute Inc. Cary, NC. USA). Continuos values were expressed as mean±SD.Differences between groups were examined by student’s t test, and statistical difference was considered when the P value was less than 0.05.Results 1)The height in “desert people” was significantly taller than that in controls.P value was 0.0317 for male and P<0.0001 for female, respectively. The body mass index (BMI,kg/m2)was smaller in “desert people” than that in controls,with 21.38 vs 23.84 for male and 21.27 vs 23.62 for female,and all P was less than 0.05.(2)Blood pressure (both SBP and DBP) increased with age increasing in “desert people”, and both SBP and DBP levels were lower than those in controls within the same age group. However, systolic blood pressure was significantly lower than that in control.Only within both group of 18~45 and age>60 years,P value was 0.0127 and 0.0443,respectively.(3)The prevalence of hypertension in “desert people” was 7%（24/359）,that was significantly lower than that in controls(307%,31/101),P<0.0001.(4)The levels of TG,TC,LDL-C, Apo-A, Apo-B in serum were significantly lower in the “desert people”,than those in the controls,with P value changing region from 0.0248 to 0.0001, except for TG in the group of 18~45 years. (5)Immunological determinations showed that the levels of IgG, IgA and IgM were lower in “desert people” than those in controls,and P value was 0.0299 and <0.0001,respectively.(6)Based on the data from the questionare information, “desert people” had very low salt loading for every day, and there was little people with smoking and no drinking.ConclusionThe preliminary results showed that the physiological characteristics with low BMI, blood glucose and the low levels of TG,TC,LDL-C, Apo-A, Apo-B, as well as their habits of low salt loading, little smoking and no drinking, these factors might be associated with the low prevalence of hypertension in the “Desert people” |
