| 基于UPLC-Q-TOF的经前期综合征肝气逆证大鼠模型代谢表征研究 |
| 投稿时间：2009-10-20 修订日期：2009-12-03 点此下载全文 |
| 引用本文：张惠云、罗国安、孙鹏、乔明琦、黎莉、黄浩、魏娜、魏盛.基于UPLC-Q-TOF的经前期综合征肝气逆证大鼠模型代谢表征研究[J].医学研究杂志,2010,39(1):29-34 |
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| 摘要点击次数: 1268 |
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| 基金项目:“十一五”国家科技支撑计划“调肝方药干预经前期综合征肝气逆证的代谢机制”（2006BAI08B05-10） |
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| 中文摘要:目的研究经前期综合征（PMS）肝气逆证大鼠代谢指纹差异，以期为PMS肝气逆证在代谢层次上的发病机制寻找证据。方法用电刺激法复制经前期综合征肝气逆证大鼠模型，UPLC-TOF-MS法检测各组大鼠尿液的代谢指纹变化。结果对照组、造模组在主成分分析中得到了较好的区分，给予白香丹胶囊后代谢网络有修复趋势。结论利用代谢组学能够较好地区分PMS肝气逆证模型大鼠代谢模式及药物调控趋势，该方法可为情志病证发病机制及模型评价研究提供新手段，显示出代谢组学在中医证候研究中的可行性。 |
| 中文关键词:经前期综合征、肝气逆证、代谢组学 |
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| Study on the Metabolic Pattern of Premenstrual Syndrome (PMS) Liver-Qi Invasion Model Rats Based-UPLC-Q-TOF |
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| Abstract:ObjectiveTo study the difference of premenstrual syndrome liver-Qi invasion rats metabolic fingerprint cards,with a view to find the evidence of the premenstrual syndrome liver-Qi invasion pathogenesis in metabolic levels.MethodsWe copied the premenstrual syndrome liver-Qi invasion model rats by electric stimulation and detected the metabolic fingerprint changs of rats in each group by UPLC-Q-TOF.ResultsThe control group and the model group got well distingushed by analysis of PCA.Metabolic system had a restoration trend after dosing Baixiangdan Capsule.ConclusionUsing metabonomics can well distinguish the premenstual syndrome liver-Qi invasion model rats and the drug-control mode trends.The method can provide new means for the emotional diseases pathogenesis and the evaluation of models，which showed feasibility of metabonomics on zheng-study of Traditional Chinese Medicine. |
| keywords:Premenstrual syndrome Liver-Qi invasion Metabonomics |
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