| 大电导钙敏感钾通道在人足月妊娠子宫平滑肌组织中的表达 |
| 投稿时间：2009-10-10 点此下载全文 |
| 引用本文：戴凌、沙金燕.大电导钙敏感钾通道在人足月妊娠子宫平滑肌组织中的表达[J].医学研究杂志,2010,39(1):34-37 |
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| 基金项目:国家自然科学基金（30571961） |
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| 中文摘要:目的了解大电导钙敏感钾通道（large-conductance calcium-sensitive potassium channel，BKCa）蛋白在人足月妊娠未临产及临产子宫下段平滑肌组织中的表达情况，探讨BKCa在分娩启动中的作用。方法采用Western blot分别测定人足月妊娠未临产及临产子宫下段平滑肌组织中BKCa蛋白α亚单位的表达。结果人足月妊娠未临产子宫下段平滑肌组织中BKCa蛋白α亚单位的相对表达量为1.18+0.20 (n=9)，足月妊娠临产子宫下段平滑肌组织中BKCa蛋白α亚单位的相对表达量为0.60+0.08(n=11)，二者统计学差异显著(P=0.009)。结论人足月妊娠未临产子宫下段平滑肌组织BKCa 蛋白的表达高于临产子宫下段平滑肌组织，提示BKCa在宫缩发动中具有一定作用。 |
| 中文关键词:大电导钙敏感钾通道、妊娠、子宫平滑肌、分娩、Western 印迹杂交 |
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| Expression of Large-Conductance Calcium-sensitive Potassium Channels in Human Term Myometrium |
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| Abstract:ObjectiveTo investigate the expression of large-conductance calcium-sensitive potassium channel (BKCa) in myometrium.MethodsThe expression levels of BKCa α subunit protein in human myometrium tissues in term of non-labor(TNL) and term labor（TL）were measured by Western blot analysis. ResultsRelative abundance of BKCa channel α subunit protein was 1.18+0.20 for TNL group(n=9),and 0.60+0.08 for TL group(n=11).The statistic difference was significant (P=0.009). ConclusionExpression of BKCa channel protein in lower segment myometrium of TNL group was higher than that of TL group. BKCa may play a certain role in modulating uterine function. |
| keywords:Pregnant Myometrium Parturition Large-conductance calcium-sensitive potassium channel Western blot |
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