| 醛固酮拮抗剂联合血管紧张素Ⅱ受体阻断剂对高血压左心室肥厚逆转作用 |
| 投稿时间：2009-10-26 修订日期：2009-12-03 点此下载全文 |
| 引用本文：高文谦、朱平、武强、郭豫涛.醛固酮拮抗剂联合血管紧张素Ⅱ受体阻断剂对高血压左心室肥厚逆转作用[J].医学研究杂志,2010,39(1):47-49 |
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| 中文摘要:目的探讨醛固酮拮抗剂与血管紧张素Ⅱ受体阻断剂联合应用对高血压左心室肥厚的治疗作用。方法对门诊60岁以上高血压患者经多普勒彩色超声心动检查确诊为左心室肥厚患者45例, 分两组分别服用醛固酮拮抗剂与血管紧张素Ⅱ受体阻断剂（A组）或利尿剂与血管紧张素Ⅱ受体阻断剂（B组）48周, 分别测定治疗前后血压变化和左心室肥厚指标变化。结果两种降压方案均能显著降低血压，降压效果在两组间比较并无显著差异；在改善左心室肥厚和降低左心室重量指数方面，两种降压方案均有逆转左心室肥厚的作用，但A组降压方案优于B方案。结论醛固酮拮抗剂联合血管紧张素Ⅱ受体阻断剂是一个有效地逆转左心室肥厚的联合治疗方案。 |
| 中文关键词:高血压、左心室肥厚、血管紧张素Ⅱ受体阻断剂、醛固酮拮抗剂、老年人 |
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| Observation of the Additional Efficiency of Aldosterone Blockers During Angiotensin Ⅱ Receptor Blockers Treatment on Hypertensive Left Ventricle Hypertrophy |
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| Abstract:ObjectiveTo evaluate the additional efficiency of aldosterone blockers (AB) during angiotensin Ⅱ receptor blockers (ARB) treatment on hypertensive left ventricle hypertrophy in the elderly. MethodsForty-five cases of hypertensive left ventricular hypertrophy detected by Doppler ultrasonic cardiogram examination were enrolled, and were randomized to receive treatment with ARB plus AB (Group A) or ARB plus diuretics (Group B) for 48 weeks. The indicators of left ventricle hypertrophy were checked before and after the treatment. ResultsThe both regimens could significantly decrease the blood pressure, and there was significant difference in the effects on lowering blood pressure between the regimens. Both regimens could alleviate left ventricle hypertrophy, but the regimen of ARB plus AB was superior to the regimen in Group B. ConclusionThe addition of AB treatment during the ARB treatment was a good antihypertensive regimen for reducing left ventricle hypertrophy. |
| keywords:Hypertension Left ventricle hypertrophy Angiotensin Ⅱ receptor blockers Aldosterone blockers The elderly |
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