| 不同病因导致的应激性胃黏膜损伤及其血液ET、TNF-α的改变 |
| 投稿时间：2009-09-21 修订日期：2009-12-03 点此下载全文 |
| 引用本文：张宏亮、徐杨、范晓.不同病因导致的应激性胃黏膜损伤及其血液ET、TNF-α的改变[J].医学研究杂志,2010,39(1):67-70 |
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| 中文摘要:目的探讨不同病因导致的应激性胃黏膜损伤改变及其血液中ET 、TNF-α的浓度变化及二者的关系。方法通过建立急性甲胺磷中毒及急性心肌梗死动物模型，采用胃黏膜溃疡指数评定是否发生胃黏膜损伤，应用放射免疫分析法测定应激性胃黏膜损伤时血液中ET、TNF-α的变化。结果（1）成功建立大鼠急性甲胺磷中毒及急性心肌梗死动物模型。（2）急性甲胺磷中毒及急性心肌梗死两种应激状态下胃黏膜发生了损伤。（3）不同病因所致应激性胃黏膜损伤时血液中ET、TNF-α浓度增加。结论（1）临床危重疾病的应激状态下胃黏膜发生了损伤，胃黏膜溃疡指数增加。（2）不同病因所致的应激性胃黏膜损伤时血液中ET、TNF-α浓度增加，表明ET、TNF-α在应激性胃黏膜损伤时有重要作用。 |
| 中文关键词:应激、溃疡指数、内皮素、肿瘤坏死因子 |
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| Study of the Changes of Endothelin，Tumor Necrosis Factor in Different Stress-related Gastric Mucosal Disease |
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| Abstract:ObjectiveTo observe the changes of Endothelin,Tumor Necrosis Factor in different stress； and to explore the corelation between the changes of Endothelin,Tumor Necrosis Factor and the occurrence of stress-related gastric mucosal disease.MethodsThe models of the acute methamidophos poison and the acute myocardial infarction in rats were made.The gastric ulcer index was counted and the content of blood plasma Endothelin and blood serum Tumor Necrosis Factor were checked.ResultsModels of the acute methamidophos poison and the acute myocardial infarction in rats were set up successfully. The gastric ulcer index of rats in the stress groups increased .The blood plasma Endothelin and blood serum Tumor Necrosis Factor in the stress group were significantly higher than those in the control group.ConclusionThe gastric mucosal disease under different stress was observed with the gastric mucosal ulcer index.The blood plasm Endothelin and blood serum Tumor Necrosis Factor under different stress were increased，suggesting they play an important role in this phenomenen. |
| keywords:Stress Ulcer index, Endothelin Tumor necrosis factor |
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