| 原发性肾小球疾病患者血清、尿Cystatin C与肾脏病理变化的关系 |
| 投稿时间：2009-07-07 点此下载全文 |
| 引用本文：孙秀丽、其木格、陈爱珍.原发性肾小球疾病患者血清、尿Cystatin C与肾脏病理变化的关系[J].医学研究杂志,2010,39(1):74-77 |
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| 中文摘要:目的探讨在不同病理类型原发性肾小球肾炎（PGN）患者血清、尿Cystatin C(CysC)水平的差异性及其与肾脏病理变化的关系。方法对行经皮肾穿刺患者检测血清和尿中的Cystatin C，分别与肾小球评分以及肾小管间质评分进行相关性分析。结果在不同病理类型PGN 中发现，IgA肾病（IgAN）、局灶增生性肾小球病(FSGS)、膜性肾病（MN）患者的血清、尿Cystatin C浓度与正常对照组比较差异有统计学意义(P<0.05)，血清Cystatin C与肾小球评分有高度相关性，尿Cystatin C与其相关性相对弱，而与肾小管间质评分的强相关性要优于血清Cystatin C。结论在肾脏病理评估中，任一检测血清Cystatin C或尿Cystatin C均能很好地反映慢性肾脏病（CKD）的病理情况，尤其对肾小管间质病变有很大的临床意义。 |
| 中文关键词:血清Cystatin C、尿Cystatin C、肾脏病理 |
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| Correlation of Serum Cystatin C,Urinary Cystatin C and Renal Pathology in Primary Glomerulonephritis Patients of Different Patological Types |
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| Abstract:ObjectiveTo investigate the variability of serum Cystatin C concentration and urinary Cystatin C concentration in primary glomerulonephritis patients of different patological types,and to study the correlation with renal pathological changes. MethodsUrinary Cystatin C was detected before renal biopsy.The two indexes were processed by correlation analysis with glomcrulus scores and renal tubulointerstitial scores respectively.ResultsThe differences of Serum Cystatin C concentration and urinary Cystatin C concentration in IgA nephropathy(IgAN) group,focal segmental glomerulosclerosis group and membranous nephropathy group existed statistical significance as compared to normal control (P<0.05).The level of serum Cystatin C was highly correlated with glomcrulus scores,which had an advantage over the level of urinary Cystatin C and glomcrulus scores.But the strong relationship between urinary Cystatin C concentration and renal tubulointerstitial scores was better than that between serum Cystatin C concentration and renal tubulointerstitial scores. ConclusionThe detection of serum Cystatin C or urinary Cystatin C may both reflect pathological changes of chronic kidney disease well.Especially,it has important clinical significance about estimating renal tubulointerstitial damage,in spite of the difference of serum Cystatin C and urinary Cystatin C laying particular emphasis on renal pathology. |
| keywords:Serum Cystatin C Urinary Cystatin C Renal pathologyCystatin C |
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