| 全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病的临床研究 |
| 投稿时间：2009-12-03 修订日期：2009-12-15 点此下载全文 |
| 引用本文：吴鹏飞,孔荣,邱宏春,王勇.全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病的临床研究[J].医学研究杂志,2010,39(3):123-125 |
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| 中文摘要:摘要目的研究全反式维A酸联合三氧化二砷治疗急性早幼粒细胞性白血病可产生的协同作用。方法我们对我院2006～2008年共9例急性早幼粒细胞性白血病采用两药联合化疗，予ATRA 10mg 口服3～4次/天、As2O3 10mg 静脉滴注 3～4h 每天1次，于第3天加用蒽环类抗肿瘤抗生素药物+阿糖胞苷化疗。结果联合治疗患者6例初发全部一疗程达到完全缓解（CR），复发病例中2例CR，中位时间30.12±4.89天。结论联合应用ATRA+ As2O3和蒽环类抗肿瘤抗生素药物的化疗取代以往的单药治疗，取得较好的疗效，达到完全缓解的时间缩短，血小板计数恢复快，无病生存期延长。 |
| 中文关键词:全反式维A酸 三氧化二砷 急性早幼粒细胞性白血病 治疗结果 |
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| Clinical Study of Acute Promyelocytic Leukemia Treated by the Combination of All-trans Retinoic Acid with Arsenic Trioxide |
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| Abstract:AbstractObjectiveTo observe the therapeutic efficacy of all-trans retinoic acid(ATRA) combined with arsenic trioxide(As2O3) on acute promyelocytic leukemia(APL). Methods9 patients of APL underwent ATRA with As2O3 therapy.The patients in combination group were treated with ATRA 25mg/(m2·d) and As2O3 10mg intravenously for 3 to 4 hours per day until complete remission(CR) or for 50 days.According to the white blood cell(WBC) counts, anthracycline and cytosine arabinoside(Ara-C) were added on third day. Results6 newly-diagnosed and 2 relapse patients of the combination group were CR after first treat.The medium time to CR was 30.12±4.89 days. ConclusionATRA + As2O3 with anthracycline regiment is superior to either regiment given alone to patients with APL. It is an efficient therapeutic approach to APL patients using a combination of ATRA with As2O3. |
| keywords:Leukemia Promyelocytic Acute Retinoic acid Arsenicals |
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