| 葡萄球菌临床分离株耐药性分析 |
| 投稿时间：2009-11-30 修订日期：2009-12-12 点此下载全文 |
| 引用本文：屈春燕.葡萄球菌临床分离株耐药性分析[J].医学研究杂志,2010,39(3):125-128 |
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| 中文摘要:摘要目的探讨葡萄球菌临床分离株耐药性现状，为临床医生合理使用抗生素提供科学依据。方法采用微量肉汤稀释法对216株葡萄球菌做药敏试验，同时用头孢西丁纸片扩散法检测耐甲氧西林葡萄球菌(methicillin resistant staphylococcus，MRS)。结果耐甲氧西林金黄色葡萄球菌(methicillin-resistant staphylococcus aureus ,MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(methicillin-resistant coagulase-negative staphylococci ，MRCNS）的检出率分别为53.7%和91.9%；MRSA和MRCNS对临床常用抗菌药物的耐药率明显高于甲氧西林敏感金黄色葡萄球菌（methicillin-susceptible staphylococcus aureus ，MSSA) 和甲氧西林敏感凝固酶阴性葡萄球菌（methicillin-susceptible coagulase-negative staphylococci ，MSCNS) ；绝大多数葡萄球菌对奎奴普丁/达福普丁敏感；未发现对万古霉素和利奈唑胺耐药的菌株。结论MRSA 和MRCNS 分离率上升,细菌耐药性持续增加,这都要求我们进一步加强MRS的检测和细菌耐药性监测，其对于正确合理选用抗菌药和控制细菌耐药性产生十分重要。 |
| 中文关键词:葡萄球菌 b甲氧西林抗药性 细菌药敏试验 抗药性 细菌 |
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| Analysis on Drug Resistance of Staphylococcus Isolates |
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| Abstract:AbstractObjectiveTo explore the drug resistance of Staphylococcus isolates and offer scientific basis for reasonable usage of antibiotics. MethodsMIC test was taken by broth microdilution method in 216 strains of Staphylococcus. Methicillin resistant Staphylococcus （MRS）strains were identified by Cefoxitin Kirby-Bauer disk diffusion method. ResultsThe prevalence of methicillin-resistant Staphylococcus aureus （MRSA）and methicillin-resistant coagulase-negative Staphylococci （MRCNS）was 53.7% and 91.9%，respectively.Resistant rates of MRSA and MRCNS were higher than those of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-susceptible coagulase-negative Staphylococci (MSCNS) to antimicrobial agents commonly used in clinic.Most of isolates of Staphylococcus were susceptible to synercid.All isolates were susceptible to both vancomycin and linezolid. ConclusionThe increase of isolated rates of MRSA and MRCNS and the emerging bacterial resistance warrants further enhancing the detection of MRS and the surveillance of bacterial resistance to inform the rational use of antimicrobial agents and containment of bacterial resistance. |
| keywords:Staphylococcus Methicillin resistance Bacterial susceptibility testing Drug resistance Bacterial |
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