玉米须水提物对2型糖尿病大鼠胰高血糖素的影响
投稿时间:2009-11-19  修订日期:2009-12-18  点此下载全文
引用本文:温宪春,周丽,赵健飞,刘吉成.玉米须水提物对2型糖尿病大鼠胰高血糖素的影响[J].医学研究杂志,2010,39(4):52-54
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作者单位
温宪春 黑龙江省齐齐哈尔医学院药物研究所 
周丽 黑龙江中医药大学基础医学院 
赵健飞 黑龙江中医药大学基础医学院 
刘吉成 黑龙江中医药大学基础医学院 
基金项目:齐齐哈尔市科技局指令性项目资助(SFG06-01)
中文摘要:目的探讨玉米须水提物对2型糖尿病大鼠胰高血糖素的影响。方法采用高脂高糖饲养加小剂量链脲佐菌素(STZ)诱导模拟2型糖尿病雄性SD大鼠模型,给药干预8周后,分别测定各组大鼠空腹血糖(FBG)和胰高血糖素(glucagon)的水平;免疫组化法分析胰岛中胰高血糖素的表达水平。结果与模型组比较,中、高剂量的玉米须水提物可呈剂量依赖型显著降低糖尿病大鼠FBG和glucagon的水平(P<0.05或P<0.01),明显降低胰岛细胞中胰高血糖素的表达(P<0.05或P<0.01),对胰岛细胞具有一定的保护作用。结论玉米须水提物可降低糖尿病大鼠空腹血糖和胰高血糖素,抑制胰高血糖素大量分泌,对2型糖尿病大鼠可产生一定的保护作用。
中文关键词:玉米须水提物 2型糖尿病 胰高血糖素 链脲佐菌素
 
Effect of Stigma Maydis Aqueous Extract on Glucagon in Type 2 Diabetic Rats
Abstract:AbstractObjectiveTo study the effect of stigma maydis aqueous extract(SMAE) on glucagon in type 2 diabetic rats.MethodsType 2 diabetic male Sprague-Dawley rat mode was induced by high-fat and high-sugar dietary feeds and low dose streptozotocin(STZ). After 8 weeks of treatment,levels of fasting blood glucose(FBG) and glucagon(Glu) in serum were respectively assayed.Immunohistocmical study was adopted to analyze the expression of glucagon in islet cells.ResultsCompared with model control group,SMAE of middle and high dose remarkably reduced the level of FBG and Glu(P<0.05 or P<0.01),and significantly reduced the expression of Glu in islet cells (P<0.05 or P<0.01).It possessed certain function of protecting pancreatic cells. ConclusionSAME could dominantly decrease FBG and Glu inserum,inhibit excessive secretion of Glu.Thus, SMAE may protect against type 2 diabetic rats.
keywords:Stigma maydis aqueous extract  Type 2 diabetes mellitus  Glucagon  Streptozotocin
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