| 尿总蛋白肌酐比分组评价糖尿病早期肾损伤 |
| 投稿时间：2009-12-08 点此下载全文 |
| 引用本文：叶桂云,张忠源,胡望平,池细俤,闫炳龙,张永平,王丽琴.尿总蛋白肌酐比分组评价糖尿病早期肾损伤[J].医学研究杂志,2010,39(4):105-108 |
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| 中文摘要:目的探讨以尿总蛋白肌酐比（TPCR）分组评价糖尿病早期肾损伤的应用价值。方法分析61例正常组和113例2型糖尿病(2型DM)组，测量其尿液5项指标；以尿TPCR分≥200mg/g Cr组与<200mg/g Cr组2组,分析113例与另外67例2型DM患者组，测量其尿TPCR、α-L-岩藻糖苷酶(AFU) 、亮氨酸氨基肽酶(LAP)、β2-微球蛋白（β2-MG）、尿微量清蛋白（mAlb）、尿转铁蛋白（TF）和血肌酐（Cr）、血清胱抑素-C（CysC）各5~6种指标。结果正常对照组与2型DM患者组、113例2型DM患者TPCR≥200mg/g Cr组与TPCR<200mg/g Cr组，其尿TPCR、 mAlb、β2-MG、 LAP、AFU5种指标均跟随TPCR而显著增高, 统计学差异显著（P<0.001）。67例2型DM患者TPCR≥200mg/g Cr组尿TPCR、mAlb、TF以及血清CysC均高于TPCR <200mg/g Cr组，统计学差异明显（P<0. 05）。结论以TPCR 200mg/g Cr分组或为界线是判别糖尿病人早期肾损害程度的可靠指标。 |
| 中文关键词:尿总蛋白肌酐比（TPCR） 糖尿病肾病 早期肾损伤 微白蛋白尿 |
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| Group-discrimination of Early Diabetic Renal Injury by Means of Urinary Protein/Creatinine Ratio |
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| Abstract:AbstractObjectiveTo evaluate the early kindney injury by means of urinary protein/creatinine ratio（TPCR, 200mg/gCr）through group-discrimination in mellitus diabetes patients. MethodsQualitative analysis was carried out with urine 5~6 item indexes in 113 cases of diabetes mellitus , 61 cases of heallthy people and other 67 cases of diabetes mellitus patients. 2 groups were divided by means of urinary protein/creatinine ratio（TPCR, 200mg/gCr）.ResultsIn 113 cases of diabetes mellitus , urine TPCR, mAlb, β2-MG, LAP and AFU of 38 cases in TPCR≥200mg/gCr group were significantly higher than those of 75 cases in TPCR<200mg/gCr group, and there was markable difference（P<0.001）. The result was same as above between 61 cases of healthy people and 113 cases of diabetes mellitus（P<0.001）. For 67 cases of diabetes mellitus , urine TPCR, mAlb , TF, serum CysC of 15 cases in TPCR≥200mg/gCr group were also higher than those of 52 cases in TPCR<200mg/gCr group, and there was significant difference in statistics（P<005）. ConclusionIt is a dependable method to distinguish early renal injury by grouping with TPCR 200mg/gCr in diabetes mellitus. |
| keywords:Urinary protein/creatinine ratio（TPCR） Ddiabetes nephropathy Early renal injury Microalbuminuria |
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