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扩张型心肌病患者超敏C反应蛋白水平与心功能的关系

投稿时间：2010-01-10 修订日期：2010-03-12 点此下载全文

引用本文：周恒,唐其柱,邓伟.扩张型心肌病患者超敏C反应蛋白水平与心功能的关系[J].医学研究杂志,2010,39(5):48-50

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作者	单位
周恒	湖北省武汉大学人民医院心内科/武汉大学心血管病研究所
唐其柱	湖北省武汉大学人民医院心内科/武汉大学心血管病研究所
邓伟	湖北省武汉大学人民医院心内科/武汉大学心血管病研究所

基金项目:国家博士学科点专项科研基金资助项目（20070486103）

中文摘要:目的探讨扩张型心肌病（DCM）患者超敏C反应蛋白（hs-CRP）水平与心功能的关系以及临床意义。方法比较hs-CRP正常组与hs-CRP升高组间NYHA心功能分级、左心室射血分数（LVEF）、左心室舒张末内径（LVEDD）的差异。分析不同NYHA分级患者的hs-CRP水平，并对hs-CRP与LVEF、LVEDD进行相关性分析。结果hs-CRP正常组NYHA分级为2.06±0.90级，LVEF为（38.58±5.98）%，LVEDD为58.94±6.14mm，hs-CRP升高组NYHA分级为2.89±0.88级，LVEF为（33.46±6.55）%，LVEDD为66.87±9.34mm，两组相比差异有显著性（P<0.05）。NYHAⅠ级组hs-CRP为2.66±1.80mg/L，Ⅱ级组为5.02±3.27mg/L，Ⅲ级组为5.25±3.18mg/L，Ⅳ级组为8.84±2.60mg/L，Ⅱ级组、Ⅲ级组hs-CRP水平明显高于Ⅰ级组（P<0.05），Ⅳ级组明显高于前3组（P<0.001）。hs-CRP水平与LVEF呈负相关（r=-0.438，P<0.001），与LVEDD正相关（r=0.346,P<0.01）。结论hs-CRP水平与DCM患者心功能改变相关，hs-CRP可作为DCM患者心功能恶化的预测指标。

中文关键词:扩张型心肌病 C反应蛋白心功能炎症

Correlation between High Sensitive C-reactive Protein and Cardiac Function in Patients with Dilated Cardiomyopathy

Abstract:ObjectiveTo investigate the relationship between high sensitive C-reactive protein(hs-CRP) and cardiac function in patients with dilated cardiomyopathy(DCM). MethodsWe compared the differences of NYHA classes,left ventricular ejection fraction(LVEF) and left ventricular end diastolic diameter (LVEDD) between normal hs-CRP group and elevated hs-CRP group,and analyzed hs-CRP levels of different NYHA classes,then investigated the correlation between hs-CRP and LVEF and between hs-CRP and LVEDD. ResultsThe NYHA stage,LVEF,LVEDD were 2.06±0.90,(38.58±5.98)% and 58.94±6.14mm respectively in normal hs-CRP group,while those were 2.89±0.88,（33.46±6.55）% and 66.87±9.34mm in elevated hs-CRP group,and there were significant differences between the two groups.The hs-CRP was 2.66±1.80mg/L in NYHAⅠgroup,while that was 5.02±327mg/L in Ⅱgroup, 5.25±3.18mg/L in Ⅲ group,and 8.84±2.60mg/L in Ⅳ group.Levels of hs-CRP in Ⅱgroup and Ⅲ group were both significantly higher than those inⅠgroup(P<0.05),and the levels in Ⅳ group were strikingly higher than other three groups(P<0.001). Levels of hs-CRP had negative correlation to LVEF(r=-0.438，P<0.001),and positive correlation to LVEDD(r=0.346, P<001).ConclusionIt is reasonable to believe that hs-CRP is associated with cardiac function in patients with DCM,and hs-CRP may be an useful index to predict the prognosis.

keywords:Dilated cardiomyopathy C-reactive protein Cardiac function Inflammation

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