| 获得性食管气管瘘食管改道术后旷置食管结构及屏障功能研究 |
| 投稿时间：2010-01-17 修订日期：2010-03-20 点此下载全文 |
| 引用本文：杨光,白光振,李小飞,王小平,周勇安,韩勇,姜涛,程庆书.获得性食管气管瘘食管改道术后旷置食管结构及屏障功能研究[J].医学研究杂志,2010,39(5):70-74 |
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| 中文摘要:目的探讨获得性食管气管瘘（tracheoesophageal fistula，TEF）食管改道术后旷置段食管组织结构及屏障功能的变化情况。方法对15只瘘旷置（A组）杂种犬、15只食管单纯旷置（B组）杂种犬及5只正常（C组）杂种犬的旷置段食管及正常食管进行大体标本、HE染色、透射电镜（TEM）、扫描电镜（SEM）、硝酸镧示踪观察研究。结果A组与B组犬旷置段食管组织结构及屏障功能变化一致。A、B组与C组相比：①食管组织结构发生改变，黏膜下层腺体减少、缺失；②细胞间隙增宽，桥粒数目减少，屏障功能降低，但基膜完整未见破坏，镧颗粒未能突破；③细胞间隙极易见到镧颗粒填充，呈线状分布。结论对于难治性获得性TEF，食管旷置术并食管改道术是简便、可行、有效的方法，术后并发症少，值得推广应用。 |
| 中文关键词:瘘 旷置 屏障功能 |
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| The Research of Structure and Esophageal Barrier Function of Exclued Esophagus after Esophageal Diversion Surgery in Acquired Tracheoesophageal Fistula |
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| Abstract:ObjectiveTo explore the changes of structure and esophageal barrier function of exclued esophagus after esophageal diversion surgery in acquired tracheoesophageal fistula.Methods15 canis with the fistula was exclued (A group), and 15 canis with the esophagus was single excluded but not fistula(B group), and 5 canis had normal esophagus(C group).We observed the esophageal sample, H-E, transmission electron microscope(TEM), the scanning of electron microscope(SEM) and Lanthanum trace labeling. Results Changes of structure and esophageal barrier function of exclued esophagus in A group were identical with B group. Compared with A and B group, C group showed following changes: ①esophageal structure was changed; glandular organ in undermucous was reduced and deleted even. ②the score of the interstitial space was increased; the number of desmosome was decreased, and the esophageal barrier function was attenuated, but the basel lamina was not changed; lanthanum did not break throught it.③the interstitial space was filled with lanthanum and its shape was lineer. ConclusionFor the refractory acquired TEF,esophageal exclusion surgery was convenient, easy, and effective. So the method deserves to be generalized. |
| keywords:Fistula Opend Barrier function |
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