| 不同类型脑血管狭窄患者血清中的NO含量及NOS活性 |
| 投稿时间：2010-01-04 修订日期：2010-03-14 点此下载全文 |
| 引用本文：梁建涛,王振宇.不同类型脑血管狭窄患者血清中的NO含量及NOS活性[J].医学研究杂志,2010,39(5):75-78 |
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| 中文摘要:目的研究不同脑血管患者血清中血管活性因子NO含量及TNOS/iNOS活性的变化，分析这几种因素在脑血管狭窄中的可能作用机制。方法通过生化分析检测血清中一氧化氮（NO）的含量及组织型一氧化氮合酶（TNOS）和诱导型一氧化氮合酶（iNOS）的活性。结果血清NO及TNOS和iNOS的检测发现, 混合组(P=0.000)和MCA组(P=0.001)血清总的NO含量显著增高；颅内组(P=0.004)和MCA组(P=0.002)血清iNOS活性显著增加；颅内组血清TNOS活性显著减弱(P=0032)，混合组(P=0.011)和MCA组(P=0.018)TNOS活性显著增加。结论多种相关因子的参与是目标人群某些类型脑血管狭窄发生机制的重要组成部分。这为寻找脑血管狭窄的多因素多环节作用机制提供了坚实的理论基础。 |
| 中文关键词:脑血管狭窄 动脉粥样硬化 一氧化氮 一氧化氮合酶 |
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| Serum NO and NOS in Different Kinds of Cerebral Vascular Stenosis |
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| Abstract:ObjectiveTo search for the mechanism of NO and TNOS/iNOS in cerebral vascular stenosis, the changes of these serum factors in different kinds of cerebral vascular stenosis were studied. MethodsBiochemistry assays were adopted，to analyze serum NO and TNOS/iNOS in different vascular stenosis group. ResultsSerum NO contents of ′ Mix′ (P=0.000) or ′ MCA′ (P=0.001) significantly increased. INOS activity of ′ In′ (P=0.004) and ′ MCA′ (P=0.002) markedly increased. And TNOS activity of ′ In′ group significantly weakened (P=0.032), but the TNOS activity of ′ Mix′ (P=0.011) and ′ MCA′ (P=0.018) group markedly intensified. ConclusionNO and TNOS/ iNOS partly participate in the occurrence mechanism of cerebral vascular stenosis. And the study provided theory basis for studying multiple factors of cerebral vascular stenosis. |
| keywords:Cerebral vascular stenosis Atherosclerosis NO NOS |
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