| 234例局限期小细胞肺癌综合治疗结果分析 |
| 投稿时间：2009-11-20 点此下载全文 |
| 引用本文：周宗玫,陈东福,王绿化,梁军,王凯,张世平,肖泽芬,张红星,冯勤付,欧广飞,张湘茹,殷蔚伯.234例局限期小细胞肺癌综合治疗结果分析[J].医学研究杂志,2010,39(5):78-81 |
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| 中文摘要:目的回顾性分析局限期小细胞肺癌的治疗情况，并评价不同治疗方式的疗效和预后因素。方法经病理和组织学证实的局限期小细胞肺癌234例，行化疗或化放疗的综合治疗，其中单纯化疗组22例，化疗+放疗组39例，化疗+放疗+化疗组173例。化疗以CE（PE）、CAP、CAV方案为主，一般疗程为4~6周期。放疗采用6MV-X线直线加速器，照射范围包括原发灶、肺门及同侧纵隔。先行前后对穿照射4周，然后改斜野避开脊髓补量2周，使总量达56~60Gy/5~6周。结果全组总的中位生存时间为19个月，1年生存率为76.5%，2年生存率为38.2%，3年生存率为25.3%，5年生存率为15.6%。化疗+放疗+化疗组的生存率明显高于化疗+放疗组和单纯化疗组，具有显著差异（P<0.001）。治疗方式和临床分期对预后产生明显影响 （分别为P<0.001, P=0.001）。结论化疗+放疗+化疗的综合治疗对局限期小细胞肺癌的治疗取得较好的效果，临床分期及治疗方式对预后产生明显影响。 |
| 中文关键词:癌 小细胞肺/放射疗法 癌 小细胞肺/化学疗法 综合治疗 |
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| A Retrospective Study for the Limited-stage Small Cell Lung Cancer Patients with Combined Modality Treatment：An Analysis of 234 Patients |
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| Abstract:ObjectiveTo evaluate the treatment effects of chemotherapy comparing with chemotherapy and radiotherapy in the limited-stage small cell lung cancer (SCLC). Methods234 patients were cyto-pathologically diagnosed and staged as limited small cell lung cancer. The patients were treated with combined chemotherapy and radiotherapy，in which 22 cases were treated by alone chemotherapy (C), 39 patients by chemotherapy plus radiotherapy(C+R), and 173 cases by combined chemotherapy and radiotherapy + chemotherapy (C+R+C). The chemotherapy regimen included CE (or PE), CAP or CAV for 4~6 cycles. Irradiation treatment covering the primary tumor, the ipsilateral hilar nodes and mediastinum was delivered once daily with 6 megavoltage X-ray beam to a median irradiation does of 56 Gy being given in 5~6 weeks. ResultsThe 1-, 2-, 3-, and 5-year overall survival rates were 76.5%, 38.2%, 25.3%, 15.6% respectively,and the median survival time (MST) was 19 months. There was a significantly difference on the survival rate between C+R+C group and C+R group or C group (P＜0.001 ). Clincal stage and treatment model were the affective factor of prognosis(P=0.001,P<0.001). ConclusionFor limited stage SCLC, combined chemotherapy and radiotherapy + chemotherapy could get good local effect and OS. The stage and treatment model should affect the prognosis. |
| keywords:Carcinoma Small cell Carcinoma Small cell lung/radiotherapy Carcinoma Small cell lung/chemotherapy Combined modality therapy |
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