| 家兔非酒精性脂肪肝血生化指标研究 |
| 投稿时间：2009-12-18 点此下载全文 |
| 引用本文：李明霞,任伯绪,王昌富.家兔非酒精性脂肪肝血生化指标研究[J].医学研究杂志,2010,39(5):92-94 |
| DOI：
|
| 摘要点击次数: 1424 |
| 全文下载次数: 1126 |
|
|
| 中文摘要:目的建立不同程度家兔非酒精性脂肪肝模型，观察非酒精性脂肪肝程度与血生化指标的关系。方法选用32只新西兰家兔，随机分为对照组（n=8）和模型组3组（每组n=8），采用高脂高糖饲料建立不同程度脂肪肝模型，分别于4、6、8周检测家兔血清TG、TC、AST、ALT，并进行病理学检查。结果高脂高糖饲料喂养4周后可形成轻度的脂肪肝并出现血脂的升高，随着脂肪肝病变程度的发展，血清TG水平持续升高。结论血生化指标对脂肪肝有一定的诊断价值。 |
| 中文关键词:非酒精性脂肪肝 动物模型 血生化指标 家兔 |
| |
| Study on Blood Biochemical Indexes of NAFLD in Rabbits |
|
|
| Abstract:ObjectiveTo determine the relationship between blood biochemical indexes and severity of NAFLD by establishing various models of NAFLD with different degrees in rabbits. MethodsThirty-two healthy rabbits were randomly divided into normal control (n=8) and three experimental groups(n=24). Fatty liver animal models were established by giving high fat, high sugar diet. The serum TG,TC,AST,ALT and pathological evaluation were detected respectively after 4, 6 and 8 weeks. ResultsThe rabbits developed hyperlipidemia and slight fatty liver after four weeks. Along with the worsening of fat liver, the serum TG level kept rising.ConclusionThe blood biochemical indexes can serve as a reliable technique for diagnosing fatty liver disease in clinical. |
| keywords:NAFLD Animal model Blood biochemical index Rabbits |
| 查看全文 查看/发表评论 下载PDF阅读器 |
