| 自身免疫性肝炎合并肝纤维化指标异常对疾病预后判断意义 |
| 投稿时间：2010-01-04 点此下载全文 |
| 引用本文：骆定海,吴建胜,贾国葆,黄智铭,陈民新.自身免疫性肝炎合并肝纤维化指标异常对疾病预后判断意义[J].医学研究杂志,2010,39(5):97-100 |
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| 中文摘要:目的分析32例自身免疫性肝炎（AIH）的临床特点，探讨血清肝纤维化指标与疾病严重程度的关系，以预测预后。方法收集我院自2004年1月~2009年8月经确诊的AIH患者的住院资料，着重对临床表现进行回顾性分析。结果共32例入组病人，其中肝纤维化指标增高者共20例，正常者12例，分别检测两组的丙氨酸氨基转氨酶（ALT）、天门冬氨酸氨基转氨酶（AST）、总胆红素（TBil）、碱性磷酸酶（AKP）、γ-谷氨酰转肽酶（γ-GT）、凝血酶原时间（PT）、白细胞（WBC）、ANA效价对数、IgG、IgA水平，其中两组ALT值分别为383±305U/L、150±93U/L ,AST分别为275±139U/L、156±140U/L ，ANA效价对数分别为2.07±0.57g/L、1.60±0.16g/L、IgG为22.9±6.45g/L、12.1±4.17g/L，差异显著（P<0.05）。结论肝纤维谱指标反映病情严重程度，与血清透明质酸、Ⅲ型前胶原末端肽正常组比较，指标偏高组临床表现重，可以指导治疗及预测预后。 |
| 中文关键词:自身免疫性肝炎 肝纤维化指标 病情 |
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| The Significance of Abnormal Serum Fibrosis Index to the Prognosis of Autoimmune Hepatitis |
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| Abstract:ObjectiveTo analyze the clinical features of 32 autoimmune hepatitis patients，and discuss the relationship between serum fibrosis index and the severity of disease in order to predict the prognosis. MethodsWe collected the data of the patients with autoimmune hepatitis who were diagnosised in the First Affiliated Hospital of Wenzhou Medical College from January 2004 to March 2009. And the analysis was focused on retrospective analysis of clinical manifestations. ResultsA total of 32 patients were enrolled in this study. Of those cases,liver fibrosis indexes in 20 cases were increased, and 12 patients were normal.ALT, AST, TB, AKP, y-GT, PT, WBC, ANA titer log, IgG, IgA levels were detected in the two groups.The ALT value in two groups was 383±305U/L，150±93U/L，respectively.The AST value in two groups was 275±139U/L,156±140U/L respectively，and ANA titer log was 2.07±0.57,1.60±0.16 respectively，and IgG value was 22.9±6.45g/L,12.1±4.17g/L respectively.The difference was significant（P<0.05）. ConclusionCompared with normal group，the clinical manifestations of patients with high serum hyaluronic acid and Ⅲ procollagen propeptide were more serious.Indexes of liver fibrosis can reflect the severity of disease,and can guide treatment and predict prognosis. |
| keywords:Autoimmune hepatitis Serum fibrosis index State of an illness |
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