| 尿液中转化生长因子β1和层粘连蛋白含量与乳腺癌的相关性研究 |
| 投稿时间：2010-01-18 修订日期：2010-04-07 点此下载全文 |
| 引用本文：陈东祥,许汝青,盛波,陈洪俊.尿液中转化生长因子β1和层粘连蛋白含量与乳腺癌的相关性研究[J].医学研究杂志,2010,39(6):76-79 |
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| 基金项目:湖北省荆州市科技发展计划项目(20071PE1-34) |
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| 中文摘要:目的探讨尿液中转化生长因子β1（TGF-β1）和层粘连蛋白(LN)与乳腺浸润性导管癌的相关性。方法采用夹心法酶联免疫吸附技术（ELISA）分别检测60例乳腺癌患者、32例乳腺良性疾病患者及32例健康对照者尿液TGF-β1及LN的含量。结果乳腺癌组尿液LN含量高于良性病变组和对照组,差异均有显著性(P<005)，乳腺癌组尿液TGF-β1含量与良性病变组和对照组相比,差异无显著性(P>0.05)。但在乳腺癌进展期患者尿液TGF-β1含量均明显升高，差异有统计学意义(P＜0.05）。等级相关分析：尿液TGF-β1和LN含量与临床分期和淋巴结转移状况呈显著性正相关（r＝0.598/0.560,P=0.001;r＝0.647/0.602,P＝0.000/0.000）;与雌激素受体、C-erbB-2呈负相关（r＝-0.263/-0.311,P＝0.042/0.016;r＝-0.288/-0.330,P＝0.026/0.010）。结论乳腺癌患者尿液中TGF-β1及LN含量与临床分期和淋巴结转移状况呈正相关，提示TGF-β1和LN与乳腺癌的病理机制及浸润、转移等生物学行为有密切关系。 |
| 中文关键词:尿液 转化生长因子β1 层粘连蛋白 乳腺肿瘤 |
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| Correlation between Urine Levels of Transforming Growth Factor β1 and Laminin and Breast Cancer |
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| Abstract:ObjectiveTo investigate the relationship between urinary transforming growth factor β1 and laminin levels and breast cancer. MethodsThe urine levels of TGF-β1 and LN were measured by enzyme linked immunosorbent assay（ELISA）in 60 patients with breast cancer,32 patients with breast benign disease,and 32 healthy controls. ResultsThe urine level of LN of the breast cancer group was significantly higher than those of the breast benign disease group and the control group(P<0.05). Comparing the breast benign disease group and control group with the breast cancer group, the urine level of TGF-β1 had no significant difference(P>0.05). However, the urine levels of TGF-β1 in patients with more advanced were significantly higher(P<0.05). In Spearman rank correlation analysis, the urine levels of TGF-β1 and LN were significantly positive correlated with the clinical stage and lymph node status（r＝0.598/0560,P=0.001; r＝0.647/0.602,P＝0.000/0.000）, and meanwhile they were significantly negative correalted with the ER and C-erbB-2（r＝-0.263/-0.311,P＝0.042/0.016;r＝-0.288/-0.330,P＝0.026/0.010）.ConclusionUrine TGF-β1 and LN content in the Patients with breast cancer clinical stage and lymph node metastasis were positively correlated, suggesting that TGF-β1 and LN we closely related to the pathogenesis,invasion and metastasis of breast cancer. |
| keywords:Urine TGF-β1 LN Breast tumor |
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