| 中国人群HER2基因655位密码子多态性与胃癌的关系 |
| 投稿时间：2010-04-22 修订日期：2010-05-11 点此下载全文 |
| 引用本文：冯丹,攸璞,安伟,柳伟伟,王雅杰.中国人群HER2基因655位密码子多态性与胃癌的关系[J].医学研究杂志,2010,39(7):46-48 |
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| 基金项目:上海市重点学科资助项目（B905） |
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| 中文摘要:目的探讨HER2基因Ile655Val多态性在中国人群中的分布特点及其与胃癌的易感性、临床病理特征等方面的关系。方法运用聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）法检测210例胃癌患者和278例正常对照者HER2基因655位基因型，分析其与胃癌发病风险及临床病理分期之间的关系。结果与Ile/Ile 基因型相比，Val/Val基因型患者发病风险OR值为3.15（95%CI=1.07~6.71）；Ile/Val基因型的发病风险OR值为1.90（95%CI=1.18~3.10）。携带Val等位基因者与Ile纯合子相比，进展期（T2~T4）病例分别为55/98（P=0.021）；淋巴结阳性（N1~N3）病例分别为44/71（P=0.019）；远处转移（M1）病例分别为23/31（P=0.051）；低分化病例分别为35/55（P=0.002）。结论HER-2基因Ile655Val多态性与胃癌的易感性存在相关。与Ile/Ile 基因型相比，Val/Val基因型患者发病风险最高，Ile/Val基因型的发病风险次之。Ile655Val突变的病例，在病理学上显示出浸润深度深、多有淋巴结转移、低分化比例高的特点，与出现远处转移无明显相关性。 |
| 中文关键词:胃癌 HER2 单核苷酸 多态性 |
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| Association Between HER2 Codon 655 Single Nucleotide Polymorphism and Gastric Cancer Cases in Chinese People |
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| Abstract:ObjectiveTo investigate the association between Ile/Val single nucleotide polymorphism (SNP) of HER2 at codon 655 and the gastric cancer cases of Chinese people in susceptibilities and clinical pathological features. MethodsThe polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze the genotypes of 210 gastric cancer patients and 278 healthy individuals. The association of this polymorphism with the risk and pathological characteristers of gastric cancer was explored. ResultsThe OR of Val/Val genotype revealed a significantly enhanced risk of 3.15 (95%CI=1.07~6.71) compared to Ile/Ile genotype. Ile/Val genotype showed an intermediate risk of 1.90 (95%CI=1.18~3.10).Ile/Ile genotype vs Ile/Val or Val/Val genotype was 55 vs 98 in advanced cases （P=0.021）, 44vs71 in lymph node positive cases（P=0.019）, 23vs31 in metastasis cases（P=0051）, 35 vs 55 in poorly deferation cases(P=0.002). ConclusionThe Ile655Val polymorphism of the HER-2 gene was associated with the susceptibility to gastric cancer.Compared to those with Ile/Ile genotype,the individuals carrying Val genotype had a higher risk for developing gastric cancer. Val allele was associated with deeper tumor invasion, more lymph node metastasis and more poorly deferation.There was no significant correlation between Val allele and metastasis. |
| keywords:Gastric cancer HER2 Single nucleotide polymorphism |
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