| 怡力康对运动性疲劳大鼠骨骼肌能量代谢的影响 |
| 投稿时间：2010-02-11 修订日期：2010-04-20 点此下载全文 |
| 引用本文：李湘奇,张笃超,王毅.怡力康对运动性疲劳大鼠骨骼肌能量代谢的影响[J].医学研究杂志,2010,39(7):56-58 |
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| 基金项目:山东省2007年科技发展计划项目(2007GG30008005) |
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| 中文摘要:目的探讨怡力康对运动性疲劳大鼠骨骼肌能量代谢的作用机制。方法72只健康大鼠随机分为安静对照组、运动对照组、西洋参含片组、怡力康小剂量组、怡力康中剂量组、怡力康大剂量组，每组12只，采用游泳疲劳造模，同时分别给与纯净水、西洋参含片、怡力康（含片）灌服，均每天1次，连续21天后检测各组动物血清胰岛素样生长因子（IGF-Ⅰ）、乳酸（LH）、尿素氮（BUN）含量和骨骼肌能量代谢相关酶（LDH、MDH）活性。结果各游泳组大鼠血清IGF-Ⅰ含量，骨骼肌LDH、MDH活性显著高于安静对照组 (P<0.01)，西洋参含片组、怡力康各剂量组高于运动对照组（P<0.01）；各药物组大鼠血清LH、BUN含量低于安静对照组及运动对照组（P<0.01）。结论怡力康能够提高血清IGF-Ⅰ含量，骨骼肌能量代谢相关酶LDH、MDH的活性，降低血清LH、BUN含量，提高机体能量代谢,加速乳酸及尿素氮的消除，提高机体抗疲劳能力。 |
| 中文关键词:运动性疲劳 怡力康 胰岛素样生长因子 能量代谢 |
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| Effects of Yilikang on Skeletal Muscle Energy Metabolism in Rats with Exercise-induced Fatigue |
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| Abstract:ObjectiveTo explore the mechanism of yilIkang on skeletal muscle energy metabolism in rats with exercise-induced fatigue. Methods72 healthy rats were divided into 6 groups at random(12 rats for every group):rest control group, exercise training control group, American ginseng tablet group, yilikang low dose group, yilikang medium dose group, yilikang high dose group. Rats were made into the fatigue model by exhaustive swimming. Every rat at the same time was administrated pure water, American ginseng tablet or yilikang tablet respectively once a day. At the 21th day,insulin like growth factor（IGF-Ⅰ）, LH,BUN and enzymes related to skeletal muscle energy metabolism（LDH,MDH） were assayed. ResultsIt was significant higher in blood serum IGF-Ⅰ and skeletal muscle LDH,MDH to each rat in swimming group than in rest groups (P<0.01).They were higher in American ginseng tablet group and yilikang tablet group than those in exercise control group（P<0.01）.LH and BUN were lower in each medicine group than those in rest control group(P<0.01 or P<0.05）. ConclusionYilikang can improve the blood serum level of IGF-Ⅰ, and the activity of enzymes related to skeletal muscle energy metabolism（LDH,MDH）.At the same time, yilikang can reduce serum LH and serum BUN level, increase body energy apply, accelerate the clearance of LH and BUN and enhance anti-fatigue activity due to exercise. |
| keywords:Exercise fatigue Yilikang Insulin like growth factor（IGF-I） Energy metabolism |
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