| 鼻咽癌调强放疗78例临床观察 |
| 投稿时间：2010-02-05 修订日期：2010-04-20 点此下载全文 |
| 引用本文：尹宏,何志刚.鼻咽癌调强放疗78例临床观察[J].医学研究杂志,2010,39(7):91-93 |
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| 中文摘要:目的观察鼻咽癌调强放疗(IMRT)的临床疗效,急性反应和慢性损伤。方法鼻咽癌初治患者78例,按1992年福州分期标准,Ⅰ期2例,Ⅱ期38例,Ⅲ期35例,Ⅳ期3例. 全程调强放疗，总剂量69.4~73.6Gy，每次2.3 Gy。结果中位随访时间21个月(8~29个月),1、2年总生存率分别为98.7%、94.9%,局部/区域控制率分别为93.6%，91.0%，无远处转移生存率分别为92.3%，84.6%。最严重的急性毒性不良反应是放射性黏膜炎,1~4级分别为21.8%、42.3%、30.0%、1.2%。晚期毒性不良反应主要表现为口干,1级32.1%,2级7.7%，3级3.8%。 结论鼻咽癌调强放疗靶区剂量高,周围正常组织受量小,毒性不良反应轻,临床疗效令人满意。 |
| 中文关键词:鼻咽癌 调强放疗 预后 |
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| Clinical Observation of 78 Nasopharyngeal Carcinoma Patients Treated with Intensity Modulated Radiotherapy |
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| Abstract:ObjectiveTo observe the efficiency of nasopharyngeal carcinoma(NPC) treated with intensity modulated radiation therapy (IMRT) and to observe the acute and late normal tissue toxicities. Methods78 patients of first-treated nasopharyngeal carcinoma were treated with full course IMRT. According to the 1992 Fuzhou staging systm,2 patients were stageⅠ,38 patients were stageⅡ,35 patients were stage Ⅲ,and 3 patients were stage Ⅳ. The total dose was 69.4~73.6Gy,2.3Gy per fraction.ResultsThe median follow-up interval was 21 month(8~29months). The l-year and 2-years overall survival rate were 98.7%,94.9%.The local-regional control rates were 93.6%,91.0%,and the l-year and 2-year disease metastasis-free were 92.3% and 84.6%,respectively. The most serious acute toxicity was irradited inflammatin of mocosa with 21.8%,42.3%,30.0% and 1.2% from Grade 1to 4 respectively. The late toxicity was mostly salivary gland with Grade 1 (32.1%),Grade 2 (7.7%), and Grade 3 (3.8%). ConclusionIMRT could improve the target volume dose and decrease the dose of surrounding tissue resulting in higher control rate and lower side effet.The preliminary clinical result is encouraging. |
| keywords:Nasopharyngeal carcinoma Intensity-modulated radiotherapy Prognosis |
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