| 低氘水对小鼠免疫调节作用的研究 |
| 投稿时间：2010-03-07 修订日期：2010-05-31 点此下载全文 |
| 引用本文：连璐,丛峰松,蔡东联,曲丹,林宁,王洁.低氘水对小鼠免疫调节作用的研究[J].医学研究杂志,2010,39(8):72-75 |
| DOI：
|
| 摘要点击次数: 1185 |
| 全文下载次数: 1037 |
|
|
| 中文摘要:目的探讨低氘水( deuterium-depleted water, DDW )对小鼠免疫调节作用的实验研究。方法实验组小鼠以低氘水作为饮用水，对照组饮自来水，饲养6周，分别测定免疫蛋白IgG、IgM的含量，脾脏指数和胸腺指数(mg/g)，脾淋巴细胞增生能力，迟发型变态反应，NK细胞活性以及T细胞亚群CD4+和CD4+/CD8+的变化，观察低氘水对小鼠非特异性免疫和特异性免疫功能的影响。结果低氘水能显著提高IgM，脾脏指数的水平和CD4+、CD4+/CD8+的含量。结论低氘水对小鼠非特异性免疫和特异性免疫功能具有一定的增强作用。 |
| 中文关键词:低氘水 IgG IgM 迟发型变态反应 NK细胞活性 CD4+ 免疫调节 |
| |
| Effect of Deuterium Depleted Water on Immunomodulating in Mice |
|
|
| Abstract:ObjectiveTo evaluate the immunomodulating effects of deuterium-depleted water(DDW) in normal mice. MethodsAll of the mice were divided into 2 groups:the experimental group which accepted DDW as the water,and the control group. After 6 weeks, IgG, IgM, thymus index, spleen index, the proliferation of spleen lymphocytes, the activity of NK cell,CD4+,CD4+/CD8+ and dinitrofluorobenzeneinduced delayed type hypersensitivity test(DTH) were employed to evaluate the immunomodulating effects of DDW on non-specific and specific immunologic function of normal mice. ResultsDDW increased the level of IgM, spleen index, CD4+ and CD4+/CD8+.ConclusionDDW improves non-specific and specific immunologic function of normal mice. |
| keywords:DDW IgG IgM DTH The activity of NK cell CD4+ Immunomodulating |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
