| Cox-2与合并慢性活动性乙型肝炎的肝细胞癌的相关性研究 |
| 投稿时间：2010-05-20 修订日期：2010-06-23 点此下载全文 |
| 引用本文：彭浩,杨华伟,洪坚善,宋立伟,周正.Cox-2与合并慢性活动性乙型肝炎的肝细胞癌的相关性研究[J].医学研究杂志,2010,39(9):86-88 |
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| 中文摘要:目的研究环氧合酶-2（cyclooxygenase-2, Cox-2）基因在合并慢性活动性乙型肝炎的人肝细胞癌（hepatocellular carcinoma， HCC）中的表达情况，探讨及其与肝癌的相关性。方法选择52例有完整随访资料的肝细胞癌及相应癌旁组织标本，用 RT-PCR 方法检测Cox-2 mRNA 的表达情况。结果①肝癌中Cox-2 mRNA的表达明显高于癌旁组织（P＜0.05）;②肝癌组织及癌旁组织中，AFP≥400ng/ml的Cox-2表达明显高于AFP<400ng/ml，差异具有统计学意义(P<0.05);③有肝外转移的肝癌组织Cox-2表达高于无肝外转移的，差异具有统计学意义(P<0.05)。结论Cox-2基因表达上调是肝癌重要的恶性生物学指标，有助于合理评估临床转归，指导治疗。 |
| 中文关键词:环氧合酶-2（Cox-2） 肝细胞癌 相关性 |
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| Relationship between Cox-2 and Hepatocellular Carcinoma with Chronic Active Hepatitis B |
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| Abstract:ObjectiveTo investigate the expression of cyclooxygenase-2（Cox-2）in hepatocellular carcinoma (HCC) with chronic active hepatitis B and discuss their relationship. MethodsRT-PCR was used to detect Cox-2 mRNA expression in samples of HCC and corresponding adjacent liver tissue in 52 cases with HCC. Results① The level of Cox-2 expression in HCC was significantly higher than that in adjacent liver tissue (P＜0.05). ② In samples of HCC and corresponding adjacent liver tissue, the level of Cox-2 expression with AFP≥400ng/ml was higher than that with AFP<400ng/ml, and the difference was significant (P＜0.05). ③ The level of Cox-2 expression with extra-hepatic metastasis was higher than that with non-extrahepatic-metastasis, and the difference was significant (P＜0.05). ConclusionCox-2 gene expression up-graduating is an important malignant biological marker of HCC, which is helpful for assessing clinical outcome rationally and guiding therapy. |
| keywords:Cyclooxygenase-2 Hepatocellular carcinoma Relationship |
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