| uPA和PAI-1在乳腺癌血浆中的水平测定及其生物学行为的相关性研究 |
| 投稿时间：2010-04-07 点此下载全文 |
| 引用本文：汪青,鞠放,王宁,王雅杰.uPA和PAI-1在乳腺癌血浆中的水平测定及其生物学行为的相关性研究[J].医学研究杂志,2010,39(10):44-49 |
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| 基金项目:上海市科学技术委员会科研计划资助项目（06DZ19505）;上海市卫生局科研计划项目（2009113） |
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| 中文摘要:目的研究血浆中uPA和PAI-1的浓度水平和乳腺癌患者生物学行为相关性，并探讨浓度水平与乳腺癌常见免疫组化指标的相关性。方法利用免疫组化ELISA法检测88例初治乳腺癌患者血浆中uPA和PAI-1的浓度水平，并以39例健康体检者血浆为对照，结合患者的临床病理学资料分析。结果乳腺癌组血浆中uPA和PAI-1水平明显高于健康对照组（P＜0.001）;乳腺癌血浆中uPA与PAI-1浓度呈正相关（P＜0.001）；血浆uPA的浓度与乳腺癌的瘤体大小、组织学分级、临床分期、腋窝淋巴结转移分别呈正相关（P＜0.05），而与患者年龄、病理类型无关；血浆PAI-1的浓度与乳腺癌的瘤体大小、临床分期、腋窝淋巴结转移分别呈正相关（P＜0.05），而与患者年龄、组织学分型、病理类型无关；ER表达阳性乳腺癌患者，血浆uPA及PAI-1浓度值高于ER表达阴性患者（P＜0.01）；Her-2阳性的乳腺癌患者，血浆中uPA及PAI-1浓度值明显高于Her-2阴性患者（P＜0.01）。结论血浆中uPA及PAI-1高表达与乳腺癌的侵袭、转移密切相关；与ER的状态、Her-2表达之间密切相关；对uPA与PAI-1联合检测可能有助于判断乳腺癌的恶性进度及预测其生物学行为。 |
| 中文关键词:乳腺肿瘤 尿激酶型纤溶酶原激活物 人纤溶酶原激活剂抑制物-1 侵袭 转移 |
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| Relationship between Plasm Urokinase-type Plasminogen Activator (uPA) and Plasminogen Activator Inhibitor (PAI-1) Level and Biological Behaviors in the Breast Cancer Patients |
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| Abstract:ObjectiveThis study is to explore the correlation of the expression levels of uPA and PAI-1 in plasma and the clinicpathological features of breast cancer. MethodsImmunohistochemistry ELISA was used to detected uPA and PAI-1 in plasma of 88 experimental patients and 39 control populations. ResultsPlasma concentration levels of uPA and PAI-1 were significantly higher than those in the normal control group（P＜0.001）.uPA in Breast cancer patients had positive correlation with PAI-1 in the plasma concentration (P<0.01) .The concentration of uPA in plasma had positive correlation with the tumor size of the breast cancer,histological grade, clinical stage, axillary lymph node metastasis (P<0.05)，had negative correlation with the patient′s age, pathological subtype. The concentration of PAI-1 in plasma had positive correlating with breast cancer tumor size, clinical stage， axillary lymph node metastasis (P<0.05)，and had negative correlation with age, histological type, pathological subtype.Concentrations of plasma uPA and PAI-1 expression in the breast cancer patients with ER-positive expression were higher than the ER-negative patients (P<0.01).The plasma levels of uPA and PAI-1 were significantly higher in the breast cancer patients with Her-2 positive expressiol than Her-2 negative patients (P<0.01).ConclusionHigh uPA and PAI-1 expression in Breast cancer patients and tumor invasion and metastasis were closely related,and the same to the ER status and Her-2 expression.Combined detection of malignant breast cancer may help to determine the progress and predict their biological behavior. |
| keywords:Breast carcinoma Urokinase-type plasminogen activator Human plasminogen activator inhibitor-1 Nvasion Metastasis |
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