| ER阳性乳腺癌患者Her-2和PR表达的相关性研究 |
| 投稿时间：2010-04-13 点此下载全文 |
| 引用本文：王宁,王斌,王雅杰.ER阳性乳腺癌患者Her-2和PR表达的相关性研究[J].医学研究杂志,2010,39(10):55-59 |
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| 基金项目:2010年上海市卫生局科研计划项目（2009113）；上海市重点学科建设项目（B905） |
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| 中文摘要:目的研究雌激素受体（ER）阳性的乳腺癌患者中人表皮生长因子受体2（Her-2）和孕激素受体（PR）表达的关系以及对预后的影响。方法对1362例乳腺癌患者进行回顾性分析，确立ER状态，将PR与Her-2表达的关系进行比较，明确两者之间的相关性。结果对588名ER阳性乳腺癌患者进行分析发现，Her-2表达与PR状态（阴性 vs 阳性，OR：2.55，95%CI：1.29~5.03）和组织病理学分级（3级 vs 1/2级，OR：4.69，95%CI：2.16~10.19）相关。绝经前的ER阳性乳腺癌患者Her-2的表达只与组织学分级（3级 vs 1/2级，OR：4.92，95%CI：1.41~17.17）相关，而与PR表达无关。相反，绝经后的ER阳性乳腺癌患者Her-2表达与组织病理学分级无关，仅仅和PR表达（阴性 vs 阳性，OR：3.02，95%CI：1.22~7.52）有关。ER阳性乳腺癌Her-2过表达和PR表达呈负相关，与绝经状态无关。结论ER阳性乳腺癌Her-2表达与PR状态和组织病理学分级有关。绝经前的患者Her-2的表达只与组织学是否3级相关，而与PR表达无关。绝经后的患者Her-2表达与组织病理学分级无关，仅仅和PR表达有关。 |
| 中文关键词:雌激素受体 孕激素受体 Her-2 乳腺肿瘤 绝经 |
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| Association between Human Epidermal Growth Factor Receptor 2 and Progesterone Receptor Expression in the Estrogen-receptor Negative Breast Cancer Patients |
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| Abstract:ObjectiveTo understand association between PR status and Her-2 overexpression in the ER-positive breast cancer, we divided the patients by menopausal status and the relationship between PR and Her-2 was evaluated. MethodsER-positive status was identified in 1362 breast cancer patients diagnosed in Changhai Hospital (Shanghai). We examined differences between PR and Her-2 expression in relation to menopausal status, age, tumor size, histological grading, lymph node metastasis and location of the primary tumors. ResultsHer-2 overexpression was related to the status of PR and histologic grade in ER+ tumors. In the multivariates studies, histologic grade （grade 3 vs 1/2， OR：4.92，95%CI：1.41~17.17）not PR was associated with Her-2 overexpression in the premenopausal women. However, in the postmenopausal women PR （- vs +，OR：3.02，95%CI：1.22~7.52） not histologic grade was related to the Her-2. ConclusionAn inverse relationship between PR and Her-2 was confirmed in the postmenopausal not premenopausal women with ER-positive breast cancer. |
| keywords:Estrogen receptor Progesterone receptors Her-2 Breast neoplasms Menopause |
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