| 人类β-防御素-1基因多态性与慢性阻塞性肺疾病关系的研究 |
| 投稿时间：2010-04-08 点此下载全文 |
| 引用本文：孙丽蓉,张敏,李冬梅,刘柱,李水霞,高扬,张建玲.人类β-防御素-1基因多态性与慢性阻塞性肺疾病关系的研究[J].医学研究杂志,2010,39(10):81-84 |
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| 中文摘要:目的探讨人类β-防御素-1(hBD-1)基因多态性与慢性阻塞性肺病(chronic obstuctive pulmonary disease，COPD)之间的关系。方法采用病例对照研究和聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术，检测COPD患者hBD-1基因型频率分布。结果COPD组C、G等位基因频数分别是85.25%和14.75%，对照组 C、G等位基因频数分别是7333%和2667%， C等位基因在COPD组的频数明显高于健康对照组 (χ2＝5237，P<005, OR：2101，95% CI：1104~3998)。结论hBD-1基因668C/G位点基因多态性与中国北方汉族人群COPD易感性有相关性，C等位基因可能是COPD的高危险基因。 |
| 中文关键词:慢性阻塞性肺病 人类β-防御素 基因多态性 |
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| The Relationship between Human Beta-defensin-1 Polymorphism and Chronic Obstructive Pulmonary Disease |
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| Abstract:ObjectiveThis study was designed to investigate the relationship between polymorphisms of hBD-1 668 C/G loci and COPD in Chinese Han population. MethodsWe used a case-control study to compare the frequent distribution of human β-defensin-1 genetypes with a polymerase chain reaction-fragment polymorphism(PCR-RFLP)method． ResultsThe allele frequencies of 668 C and 668G were 85.25% and 14.75% in COPD smokers, and 73.33% and 26.67% in healthy smokers (P<0.05,OR was 2.101 with 95% confidence interval 1.104~3.998 ). ConclusionThe polymorphism of hBD-1 668C/G is associated with susceptibility to COPD in Chinese Han population.Furthermore, the 668C allele represents relatively higher susceptibility to COPD. |
| keywords:Chronic obstructive pulmonary disease Human β-defensin Genetic polymorphism |
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