| 胰岛素抵抗和高血压的关系 |
| 投稿时间：2010-05-07 点此下载全文 |
| 引用本文：周洁,向红丁.胰岛素抵抗和高血压的关系[J].医学研究杂志,2010,39(10):88-90 |
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| 中文摘要:目的胰岛素抵抗和高血压病的关系总是引人争议，本研究者在确定胰岛素抵抗和高血压病的关系。方法用Ｈｏｍａ-ＩＲ评估胰岛素抵抗，１６１６例入选患者详细记录人口数据和人体测量参数，收集空腹血标本，测量空腹血糖、血脂、胰岛素等，同时计算ＨＯＭＡ-ＩＲ、ＨＯＭＡ-Ｌ和ＨＯＭＡ-ＩＳ。结果和年龄、性别、腰臀比相比，高血压患者的ＨＯＭＡ-ＩＲ明显高于非高血压患者（3.69±8.02, 2.72±4.34,P＜0.05）。多变量回归分析显示：比较年龄、腰臀比、ＢＭＩ、三酯甘油、总胆固醇、空腹血糖、空腹胰岛素、ＨＯＭＡ-ＩＲ是高血压病的独立危险因素（OR=1.087，95% CI=1.051~1.119，P<0.05）。结论本研究结果提示，胰岛素抵抗和高血压相关。 |
| 中文关键词:高血压 胰岛素抵抗 HOMA-IR |
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| Relationship Between Insulin Resistance and Hypertension |
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| Abstract:ObjectiveThe relationship between insulin resistance (IR) and essential hypertension (HTN) is controvertial.The aim of this study was to determine the association between IR and HTN in a large sample.MethodsIR was estimated by homeostasis model assessment of insulin resistance (HOMA-IR).A total of 1616 individuals with or without HTN were included in this study.Demographic data and anthropometric characteristics of participants were recorded.Fasting blood samples were collected,and fasting plasma glucose (FPG),lipids,insulin were measured.HOMA-IR were also calculated.Age,sex and waist girth adjusted HOMA-IR values were compared between hypertensive and normotensive subjects.ResultsHypertensive patients had significantly higher HOMA-IR than age-,sex-,and waist girth-adjusted mormotensive individuals（3.69±8.02, 2.72±4.34,P＜0.05）.Multivariate logistic regression analysis showed that after adjusted for age,sex, waist girth, BMI, triglyceride,totle cholesterol and FPG, HOMA-IR was a significant independent predictor of hypertension in all subjects（OR=1.087,95%CI=1.051~1.119,P＜0.05）.ConclusionThis study showed that IR is associated with hypertension. |
| keywords:Essential hypertension Insulin resistance HOMA-IR |
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