| 老年及成年AMI患者心肌缺血预适应保护作用的对比分析 |
| 投稿时间：2010-04-08 修订日期：2010-04-22 点此下载全文 |
| 引用本文：冯伟萍,唐其柱.老年及成年AMI患者心肌缺血预适应保护作用的对比分析[J].医学研究杂志,2010,39(10):91-93 |
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| 中文摘要:目的研究缺血预适应对不同年龄AMI患者保护作用的异同及内在机制。 方法按年龄将66例急性心肌梗死病人分为成年组（<65岁，n=30）和老年组（≥65岁，n=36），再依据是否有梗死前心绞痛或既往心绞痛，每组各为两个亚组：缺血预适应组，无缺血预适应组。分别对各组及各亚组的基线指标、临床指标、短期预后进行回顾性分析。 结果成年组内，缺血预适应组的LVEF明显高于无缺血预适应组（P=0.041），CK-MB、心脏事件发生率明显低于无缺血预适应组（P<0.049），而老年组内，缺血预适应组的LVEF、CK-MB、心脏事件发生率，与无缺血预适应组相比无明显差异。结论缺血预适应的保护作用在老年人减弱。 |
| 中文关键词:缺血预适应 急性心肌梗死 保护作用 |
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| Comparative Analysis of Protective Effects of Ischemic Preconditioning in Different Age of AMI Patients |
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| Abstract:ObjectiveTo investigate the protective effects of ischemic preconditioning in different age of AMI patients. MethodsThe samples were divided into 2 groups: adult group (<65year, n=30) and old age group (≥65year, n=36).And then based on whether had ischemic preconditioning,each group was subdivided into two subgroups:ischemic preconditioning group and non-ischemic preconditioning group.We compared the difference of the baseline indicators,clinical parameters and short-term prognosis in groups and subgroups retrospectively. ResultsIn adult group, ischemic preconditioning group′s LVEF was higher than non-ischemic preconditioning group′s (P=0.041),and compared with non-ischemic preconditioning group,the incidence of heart failure, cardiogenic shock and death in ischemic preconditioning group was lower (P=0.049). In old age group, there was no significant difference between ischemic preconditioning and non-ischemic preconditioning group(P>0.05).ConclusionProtective effect of ischemic preconditioning decline in the elderly. |
| keywords:Ischemic preconditioning Acute myocardial infarction Protective effect |
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