生地黄汤不同配伍组成多糖含量变化及止血作用的实验研究
投稿时间:2010-06-07    点此下载全文
引用本文:张丽娟,李瑾,王梅,姜海信,郭东艳.生地黄汤不同配伍组成多糖含量变化及止血作用的实验研究[J].医学研究杂志,2010,39(11):41-43
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作者单位
张丽娟 陕西中医学院2008级研究生 
李瑾 陕西中医学院2009级研究生 
王梅 陕西中医学院附属医院制剂中心 
姜海信 陕西中医学院药学院 
郭东艳 陕西中医学院药学院 
基金项目:陕西省科技厅资助项目(2008K16-04 SJ08C239);陕西省重点学科专项建设资金资助
中文摘要:目的研究生地黄汤不同配伍组成中多糖含量变化及对止血作用的影响。方法以葡萄糖为对照品,采用蒽酮-硫酸法于622nm处测定多糖含量;给小鼠灌服不同配伍组成的生地黄汤水煎液,采用剪尾法及毛细玻管法测定各组小鼠出、凝血时间,与对照组进行比较,并进行统计学处理。结果当生地黄与大黄的比例为30∶6时止血效果最好。多糖的含量也呈现出先增后降的规律。结论多糖可能是止血的有效成分,但不一定是唯一活性成分。
中文关键词:生地黄汤  配伍  多糖  止血作用
 
Experimental Study on the Changes of the Content of Polysaccharides and its Hemostatic Effect in Shengdihuang Decoction with Different Proportion Compatibility
Abstract:ObjectiveTo study the change of the content of polysaccharides and its hemostatic effect in Shengdihuang Decoction with different proportion compatibility. MethodsAnthrone-sulfuri acid colorinetric method was used. The mice were administered with different proportion compatibility in Shengdihuang Decoction. Breaking tail hemostasia and capillary coagulation in mice were used to evaluate the hemostatic effect.These indicators were compared between the control group and experiment gronps,and were statistically analyzed. ResultsWith the increase in the amount of rheum,the content of polysaccharides increased at first and then decreased.The rate of 30∶6 was the best proportion compatibility which can strengthen the hemostatic effect. ConclusionThe polysaccharides may be one of the effective hemostatic components,but not the only one.
keywords:Shengdihuang decoction  Compatibility  Polysaccharides  Hemostatic effect
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