| 低剂量环孢素治疗难治/复发免疫性血小板减少症的疗效及安全性分析 |
| 投稿时间：2010-08-23 修订日期：2010-10-25 点此下载全文 |
| 引用本文：吴天勤,陈海飞,唐杰庆,朱晶晶,金玲娟,李征洋,沈红石,秦龙梅.低剂量环孢素治疗难治/复发免疫性血小板减少症的疗效及安全性分析[J].医学研究杂志,2010,39(12):47-49 |
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| 基金项目:全军医药卫生科研基金资助项目（08MA019） |
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| 中文摘要:目的探讨环孢素A(CyA)在难治/复发性免疫性血小板减少症（ITP)治疗中的临床疗效和不良反应。方法36例难治/复发ITP患者接受3～5mg/(kg·d）的CyA治疗并观察疗效和不良反应。结果中位随访10个月，完全反应（CR） 13例（36.1％），有效（R）15例（41.7％），无效（NR）8例（22.2％），总有效率为77.8％。复发与难治两组疗效差异比较无统计学意义（P=0.083）。常见的不良反应为胃肠道反应、头痛、血压升高及肝功能受损，多数患者能较好耐受。结论低剂量的CyA治疗ITP是一种高效、安全的挽救性治疗方法，严重不良反应较少。 |
| 中文关键词:环孢素A 难治性 复发性 原发性免疫性血小板减少症 |
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| The Efficacy and Safety of Low Dose Cyclosporine A in the Treatment of Refractory and Relapsed Immune Thrombocytopenia |
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| Abstract:ObjectiveTo explore the efficacy and safety of Cyclosporine A (CyA) int the treatment of refractory/relapsed immune thrombocytopenia(ITP). MethodsThirty-six patients with refractory/relapsed ITP were administered CyA with 3~5mg/（kg·d）. ResultsThe median follow up was ten months and the efficacy of the group was as follows: complete response in 13（36.1％）,response(R) in 15 （41.7％）, non-response(NR) in 8(22.2％). There was no significant difference in the efficacy between the refractory and relapsed subgroups. The adverse events were mild and most patients could be well tolerated. ConclusionThe high rate of responses and low and transient adverse events suggest that the oral administration of low dose CyA could be considered in severe, refractory/relapsed ITP as a salvage therapy. |
| keywords:Cyclosporine A Refractory Relapsed Primary immune thrombocytopenia |
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