| 利多卡因复合地塞米松减轻异丙酚注射痛的临床研究 |
| 投稿时间：2010-06-17 点此下载全文 |
| 引用本文：蔡勤芳,杨亚红,郑伟,刘永勤.利多卡因复合地塞米松减轻异丙酚注射痛的临床研究[J].医学研究杂志,2010,39(12):96-99 |
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| 中文摘要:目的比较利多卡因、地塞米松及利多卡因复合地塞米松3种给药方法预防异丙酚注射痛的临床效果。方法160例行择期手术的患者，随机分为对照组（C组）、利多卡因组（L组）、地塞米松组（D组）和利多卡因+地塞米松组（L+D组），每组40例。橡胶止血带阻断前臂静脉回流后，分别静脉推注C组：生理盐水；L组：利多卡因20mg，D组：地塞米松 75mg；L+D组：利多卡因 20mg复合地塞米松 7.5mg混合液。1min后松开止血带，并推注预剂量的异丙酚，［预剂量=1/4总异丙酚诱导量（按2.5mg/kg计算）］ 。各组在静脉推注异丙酚10s后询问患者疼痛情况并同时记录注射部位疼痛评分。结果4组患者异丙酚注射痛发生率分别为：对照组87.5%，利多卡因组40.0%，地塞米松组45.0%，利多卡因复合地塞米松组5.0%，与对照组相比，后3组异丙酚注射痛的发生率显著减少（P<0.05）；与利多卡因组和地塞米松组相比，利多卡因复合地塞米松组异丙酚注射痛的发生率也显著减少（P<0.05）；地塞米松组和利多卡因复合地塞米松组术后恶心、呕吐发生率更低（P<0.05）。 结论利多卡因 20mg复合地塞米松 7.5mg静脉预处理能够有效减轻异丙酚注射痛，使用地塞米松还能减少术后恶心、呕吐的发生。 |
| 中文关键词:静脉麻醉 二异丙酚 利多卡因 地塞米松 注射痛 |
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| A Clinical Study on Combination Intravenous Lidocaine and Dexamethasone for Alleviating Propofol Injection Pain |
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| Abstract:ObjectiveTo evaluate the efficacy of combination intravenous Lidocaine and Dexamethasone in alleviating propofol injection pain. Methods160 patients scheduled for operations were randomly divided into four groups: control group(group C), lidocaine group(group L), dexamethasone group(group D) and lidocaine / dexamethason group (group L+D), with 40 patients in each group. The patients in the above four groups received saline, lidocaine 20mg, dexamethasone 7.5mg and lidocaine 20mg plus dexamethasone 75mg respectively. The patients were injected with one-forth of schedulepropofol via a dorsal hand vein after one minute of venous occlusion. The pain during the injection of propofol was evaluated. ResultsPain occurred in 87.5% of patients in the control group, 40% in the lidocaine group, 45% in the dexamethasone group and 5% in the lidocaine / dexamethason combination group. There was a significant reduction in pain incidence in the three experimental groups as compared with the control group (P<0.05). The incidence of pain associated with propofol injection, nausea, vomiting was reduced significantly in the combination group than in the control group(P<005). ConclusionCombination of lidocaine 20mg and dexamethasone 7.5mg, with venous occlusion for 1 minute, was more effective than lidocaine 20mg or dexamethasone 7.5mg alone for pain control during propofol injection.Using dexamethasone may reduce the incidence of postoperative nausea and vomiting. |
| keywords:Intravenous anesthesia Propofol Lidocaine Dexamethasone Pain on injection |
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