| 氟比洛芬酯联合舒芬太尼用于小儿术后持续静脉镇痛的观察 |
| 投稿时间：2010-07-03 修订日期：2010-09-20 点此下载全文 |
| 引用本文：李煜,谢观土,张永福,姚侠,程秋菊.氟比洛芬酯联合舒芬太尼用于小儿术后持续静脉镇痛的观察[J].医学研究杂志,2010,39(12):104-106 |
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| 中文摘要:目的对比研究氟比洛芬酯联合舒芬太尼与单纯氟比洛芬酯或舒芬太尼应用于小儿术后持续静脉镇痛（PCIA）的效果和不良反应。方法择期全麻下行腹部手术患儿90例(ASA Ⅰ～Ⅱ级)，随机分为A、B、C 3组，各30例。A组：氟比洛芬酯2mg/kg+生理盐水至100ml；B组：舒芬太尼2μg/kg+生理盐水至100ml；C组：氟比洛芬酯1mg/kg +舒芬太尼1μg/kg+生理盐水至100ml。A、C组负荷剂量为氟比洛芬酯0.5mg/kg，B负荷剂量为舒芬太尼0.05μg/kg。PCA泵设置持续量为2ml/h，单次给药量为0.5ml，间隔时间20min。监测并记录术后 4、8、12、24、48h患儿的生命体征、镇痛和镇静效果及不良反应发生情况。结果3组患儿术后各时点VAS评分均小于4分，A组在4、8、12h各时点的VAS评分显著高于B和C组 (P<0.05)。A组12h内PCA给药次数显著高于B和C组(P<0.05)。B组12h内Ramsay评分显著高于A和C组(P<0.05)。A、B两组恶心、呕吐发生率显著低于C两组(P<0.05)。B组嗜睡、呼吸抑制发生率显著高于其余两组(P<0.05)；结论氟比洛芬酯联合舒芬尼术后持续静脉镇痛效果良好，可减少单独使用氟比洛芬酯或舒芬尼的用量和不良反应的发生率，是一种理想的镇痛方法。 |
| 中文关键词:氟比洛芬酯 舒芬太尼 静脉镇痛 小儿 |
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| Effect of Flurbiprofen Axetil Combined with Sufentanil for Intravenous Postoperative Analgesia in Children |
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| Abstract:ObjectiveTo evaluate the PCIA effect and side effect of flurbiprofen axetil,sufentanil and the combination of the two drugs in the children.MethodsNinety patients (ASA Ⅰ~Ⅱ) aged from 6 to 12 years underwent abdominal surgery were randomly allocated into three groups.Patients in group A and group B were administrated flurbiprofen 2mg/kg axetil and sufentanil 2μg/kg diluted to 100ml via PCIA after surgery,respectively.Patients in group C was given 1mg/kg flurbiprofen axetil plus 1μg/kg sufentanil diluted to 100 ml via PCIA after surgery.The loading dose of group A and C was flurbiprofen axetil 0.5mg/kg,while for group B was sufentanil 0.05μg/kg.The PCIA pump was set at a rate of 2ml/h,and bolus dose was 0.5ml,and lockout time interval was 20min.Postoperative vital sign,analgesia,analgesic efficacy (VAS scores) and side effects at 5 points(4,8,12,24,48hours after the operation) were recorded.ResultsVAS scores of all the groups were less than 4 at each point.VAS scores at hours 4,8,12 in the group A were significantly higher than thoese in the group B and C (P<0.05).The frequency of 12h PCA administration for group A was much higher than group B and C (P<0.05).The 12h Ramsay score in group B was higher that group A and C (P<0.05).The incidence rates of nausea,vomiting in group A and B were significantly lower than thoese in the group C (P<0.05).The incidence rates of somnolence and respiratory depression in group B were remarkably higher than thosese in group A and C.ConclusionFlurbiprofen axetil combined with sufentanil PICA has a better analgesia effect,which can decrease the dose of drug usage and incidence rates of adverse events than Flurbiprofen axetil or sufentanil alone.The combination of flurbiprofen axetil and sufentanil is satisfied for PCIA. |
| keywords:Flurbiprofen axetil Sufentanil Intravenous postoperative analgeise Children |
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