| 低渗与等渗对比剂对糖尿病肾病肾功能的影响 |
| 投稿时间：2010-06-21 点此下载全文 |
| 引用本文：刘华东,董少红,罗林杰,姜昕.低渗与等渗对比剂对糖尿病肾病肾功能的影响[J].医学研究杂志,2010,39(12):110-112 |
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| 中文摘要:目的观察低渗及等渗对比剂对糖尿病肾病（DN）患者肾功能的影响。方法选择2007年1月～2009年12月于笔者医院接受冠脉造影(CAG)和（或）介入治疗(PCI)并合并DN的164例，随机分为低渗组及等渗组。其中低渗组96例，等渗组68例，两组患者术前及术后72 h均测定血清肌酐（Scr）及半胱胺酸蛋白酶抑制剂C（CysC）水平，计算对比剂肾病的发生率。结果两组术后Scr及CysC平均峰值水平较术前有所升高，其中低渗组Scr峰值平均升高8.3μmol/L，CysC平均峰值增加008mg/L；等渗组Scr峰值平均升高7.7μmol/L，CysC平均峰值增加0.07mg/L。低渗组对比剂肾病发病率为10.4%，等渗组对比剂肾病发病率为8.8%，二者比较无明显统计学差异(P>0.05)。结论本研究中，DN患者总的对比剂肾病的发生率为98%，低渗与等渗对比剂在DN患者中对肾功能的影响无明显差异。 |
| 中文关键词:对比剂 对比剂肾病 糖尿病肾病冠 状动脉介入诊疗术 |
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| Influences of Low-osmolar versus Iso-osmolar Contrast Media on Renal Function in Patients with Diabetic Nephropathy |
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| Abstract:ObjectiveTo compare the effects of the non-ionic, iso-osmolar agent, versus the non-ionic, low-osmolar agent, on renal function in patients with diabetic nephropathy(DN). Methods164 subjects with DN undergoing diagnostic and/or therapeutic coronary angiographic procedures were divided into two groups, with 96 in low-osmolar group and 68 in iso-osmolar group. The end points were the peak increase in serum creatinine (SCr) , Cystatin C (CysC) and the incidence of contrast-induced nephropathy (CIN)．ResultsThe average levels of Scr and CysC increased in two groups，with Scr increasing 8.3μmol/L,CysC increasing 0.08mg/L in average in low-osmolar group, and Scr increasing 7.7μmol/L,CysC increasing 0.07mg/L in average in iso-osmolar group. The incidence of CIN was 10.4% in low-osmolar group and 8.8% in iso-osmolar group(P>0.05). ConclusionIn the present study, the overall rate of CIN in DN patients undergoing coronary angiographic procedures was 9.8%. There was no significant difference between low-osmolar and iso-osmolar contrast media in either peak increase in SCr and CysC, or in risk of CIN in DN patients. |
| keywords:Contrast medium Contrast-induced nephropathy Diabetic nephropathy Coronary intervention |
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