| 血浆脂联素水平下降与2型糖尿病合并慢性稳定性心绞痛患者冠状动脉病变的严重性相关 |
| 投稿时间：2010-07-24 点此下载全文 |
| 引用本文：童国新,王宁夫,杨俊,来蕾,冷建杭,叶显华,周亮,杨建敏.血浆脂联素水平下降与2型糖尿病合并慢性稳定性心绞痛患者冠状动脉病变的严重性相关[J].医学研究杂志,2011,40(1):73-77 |
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| 基金项目:浙江省医药卫生科学研究基金(2007A157) |
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| 中文摘要:目的研究血浆脂联素水平与2型糖尿病合并慢性稳定性心绞痛（DM-SAP）患者冠状动脉病变严重程度的关系。方法236例DM-SAP患者的诊断依靠冠状动脉造影确诊，采用Gensini积分计算方法评价冠脉病变的严重程度，并根据Gensini积分四分位数分成4组，另外选取138例健康体检者作为阴性对照组。所有研究对象均采用ELISA法测定血浆脂联素水平，以免疫比浊法测定血清hs-CRP水平。结果DM-SAP组血浆脂联素水平较阴性对照组明显降低(6.51±1.97μg/ml∶7.55±1.63μg/ml,P<0.001)。较高Gensini积分四分位组(组4、3和2）的DM-SAP患者其血浆脂联素水平明显低于最低四分位组(组1)(P<0.001）。DM-SAP患者脂联素水平与当前吸烟、HbA1c水平呈显著负相关(P<0.05)。多因素Logistic回归分析显示，低脂联素水平是DM-SAP患者冠脉病变严重程度的独立危险因素(OR=17.78,95%CI 6.453~49.01,P<0.001)。结论血浆脂联素水平随着2型糖尿病合并慢性稳定性心绞痛冠脉病变的严重性显著下降，表明血浆脂联素水平下降可能参与了动脉粥样硬化的病理过程。 |
| 中文关键词:脂联素 2型糖尿病 慢性稳定性心绞痛 Gensini积分 |
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| Relationship between Decreased Plasma Adiponectin and Severity of Coronary Artery Lesions in Patients with Type-2 DM and Chronic Stable Angina Pectoris |
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| Abstract:ObjectiveTo investigate the relationship between plasma adiponectin level and the severity of coronary artery lesions in patients with type-2 DM and chronic stable angina pectoris（DM-SAP）. Methods236 DM-SAP patients were diagnosed by coronary angiography,and the severity of coronary artery lesions was measured by Gensini score,then the DM-SAP patients were assigned into 4 groups according to the quartile of Gensini score, and a healthy control group(n=138) was established.Plasma adiponectin concentrations in all subjects were measured by ELISA,and serum Hs-CRP levels were measured by immunoturbidimetry. ResultsAdiponectin level in DM-SAP group was lower than that in control group (6.51±1.97μg/ml vs 7.55±1.63μg/ml,P<0.001). Adiponectin levels in the higher Gensini scores quartile groups (group 4, group 3 and group 2) were significantly lower than those in the lowest quartile group (group 1) (P<0.001). There was significant negative correlation between plasma adiponectin level and current smoking or HbA1c(P<0.05). Multivariate logistic regression analysis demonstrated that decreased adiponectin level was the significant independent risk factor of the severity of coronary artery lesions in patients with DM-SAP(OR=17.78,95%CI 6.453 to 49.01,P<0.001).ConclusionPlasma adiponectin level decreased markedly with the severity of coronary artery lesions in patients with type-2 DM and chronic stable angina pectoris, which suggested that decreased plasma adiponectin may be involved in the pathogenesis of atherosclerosis. |
| keywords:Adiponectin Type-2 DM Chronic stable angina pectoris Gensini score |
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