| 原发性肾病综合征患儿血尿IFN-γ、IL-13、TGF-β1的变化及黄芪的作用 |
| 投稿时间：2010-06-16 修订日期：2010-12-22 点此下载全文 |
| 引用本文：康国贵,周江瑾,张琦,陈惠琴,康友群.原发性肾病综合征患儿血尿IFN-γ、IL-13、TGF-β1的变化及黄芪的作用[J].医学研究杂志,2011,40(2):90-93 |
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| 中文摘要:目的探讨原性肾病综合征（PNS）患儿血、尿IFN-γ、IL-13、TGF-β1水平的变化及黄芪的干预作用。方法46例PNS患儿随机分为黄芪治疗组（Ⅰ组,n=24），PNS对照组（Ⅱ组,n=22）,观察用药前后血清及尿液IFN-γ、IL-13、 TGF-β1水平及临床转归。健康儿童20例为正常对照组（Ⅲ组）。 结果血清 IFN-γ、IL-13水平，入院时Ⅰ、Ⅱ组均显著高于Ⅲ组（P均<0.01）；缓解后其水平均虽显著下降（P均<0.01），但I组的下降明显高于Ⅱ组（P均<0.01），与Ⅲ组比较已无显著差异（P均＞0.05），而Ⅱ组仍显著高于Ⅲ组（P均＞0.05）。血清TGF-β1水平入院时Ⅰ、Ⅱ组均显著高于Ⅲ组（P均<0.01）；缓解后均显著下降，与Ⅲ组比均已无显著差别（P均＞0.05），Ⅰ组与Ⅱ组比较亦无显著差别（P＞0.05）。尿液IFN-γ、IL-13、TGF-β1水平与血清 IFN-γ、IL-13、TGF-β1水平一样用药前后也发生相同的变化。继发感染率和反复或复发率Ⅰ组均显著低于Ⅱ组（分别为50%比81.8%和33.3%比63.6%，分别χ2=5.123,4.224,P均<0.05）。感染后治愈天数Ⅰ组显著少于Ⅱ组（5.0±16天比8.0±2天,t=3.066,P<0.005）。结论IFN-γ、IL-13、TGF-β1各细胞因子可能均参与PNS的发病；黄芪对血、尿IFN-γ、IL-13有一定的调节作用。黄芪在佐治SNS中具有预防和降低感染、减少和预防反复或复发、避免反复大量应用激素的作用。 |
| 中文关键词:原发性肾病综合征 干扰素-γ 白介素-13 转化生长因子-β1 黄芪儿童 |
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| Changes of Serum and Urinary IFN-γ, IL-13 and TGF-β1 in Children with Primary Nephrotic Syndrome and Effect of Astragalus |
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| Abstract:ObjectiveTo investigate the changes of interferon –gamma (IFN-γ), interleukin-13 (IL-13) and transforming growth factor beta 1 (TGF-β1 ) in serum and urinary in children with primary nephrotic syndrome (PNS) and study the effect of astragalus. MethodsForty six children with PNS were randomly divided into two groups:astragalus granula treatment group(Ⅰ group,n=24) and prednison control group (Ⅱ group,n=22). In addition, 20 healthy children were normal control group(Ⅲ group). The treatment protocol of prednison used for 6 months was administered in two groups, while 15g (1bag) astragalus granula orally twice a day was added to children in I group for 3 to 6 months. The levels of IFN-γ, IL-13 and TGF-β1 in the serum and urin of 46 children with PNS were assayed on admission and after alleviation respectively by ELISA . The rates of remission within 8 weeks, complicated infection, and relapse within 3 months and the recovery time of infection were observed in Ⅰ group and Ⅱ group. ResultsThe levels of serum IFN-γ and IL-13 in Ⅰ group and Ⅱ group were significantly higher than those in Ⅲ group (P<0.01 for all ) on admission, and dropped markedly.There was no significant difference between group Ⅰ and group Ⅲ (P<0.01 for all ) .But they were still significantly higher in Ⅱ group than in Ⅲ group (P<0.01 for all )and obviously lower in Ⅰ group than in Ⅱ group (P<0.01 for all)after alleviation . The serum TGF-β1 in Ⅰ group and Ⅱ group were markedly increased and dropped (P<0.01 all) on admission and after alleviation respectively,and were not significant different (P>0.05 for all) as compared to Ⅲ group after alleviation . The levels of urinary IFN-γ, IL-13 and TGF-β1 were same changes with their serum values in 3 groups. The rates of complicated infection and relapse within 3 months were all significantly lower in Ⅰ group than those in Ⅱ group (50% vs 81.9% and 33.3% vs 83.6%,χ2=5.123, 4.224,respectively,P<0.05). The recovery time of complicated infection was obviously shortened in Ⅰ group comparing to Ⅱ group (5.0±1.6d vs 8.0±2.0d,t=3066,P<0.05). ConclusionIFN-γ,IL-13,TGF-β1 may be involved in the pathogenesis of PNS . Astragalus could decrease the levels of serum and urinary IFN-γ and IL-13 and may be helpful for protecting from and decreasing infection, diminishing relapse and reduling steroid dosage using in children with PNS. |
| keywords:Primary nephritic syndrome (PNS) Interferon-gama (IFN-γ) Interleukin-13 (IL-13) Transforming growth factor beta 1 (TGF-β1 ) Astragalus childrem |
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