| 绝经前后女性急性心肌梗死患者冠心病危险因素对比研究 |
| 投稿时间：2010-09-16 点此下载全文 |
| 引用本文：朱航,张瑜,董蔚,张华巍,王浩,陈思,章明.绝经前后女性急性心肌梗死患者冠心病危险因素对比研究[J].医学研究杂志,2011,40(3):94-97 |
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| 中文摘要:目的探讨绝经前后女性急性心肌梗死患者冠心病危险因素的特点。方法回顾性分析2005年1月~2010年1月解放军总医院收治的女性急性心肌梗死患者共246例，根据是否绝经及绝经年限进行分组，对各组的冠心病危险因素进行对比分析。结果绝经前组的平均体重指数、纤维蛋白原、总胆红素水平以及吸烟、低血红蛋白者比例与绝经后各组相比，差异均无统计学意义（P≥0.05）。绝经前组、绝经5年内组、绝经5~10年组的高血压和糖尿病者比例进行组间比较，差异无统计学意义（P≥0.05），绝经10年以上组高血压和糖尿病者比例均高于其他各组，差异有统计学意义（P＜0.05）。绝经前组总胆固醇、三酰甘油、LDL-C平均水平与绝经后各组相比，差异无统计学意义（P≥0.05）；绝经前组HDL-C平均水平高于绝经后各组，差异有统计学意义（P＜0.05）。绝经前组高尿酸血症者比例低于绝经后各组，差异有统计学意义（P＜0.05）。绝经前组有早发冠心病家族史者比例高于绝经后各组，差异有显著统计学意义（P＜0.01）。应用Logistic回归进行多因素分析发现绝经年限与高尿酸血症有相关性（P=0.031，OR=0.767）。结论绝经前后女性急性心肌梗死患者的冠心病危险因素有所不同，应根据不同生理阶段女性冠心病的发病特点，做好女性冠心病的早期预防和诊治工作。 |
| 中文关键词:心肌梗死 女性 绝经 危险因素 |
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| The Research of Cardiovascular Risk Factors in Pre-menopausal and Post-menopausal Female Patients with Acute Myocardial Infarction |
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| Abstract:ObjectiveTo investigate the characteristics of cardiovascular risk factors in pre-menopausal and post-menopausal female patients with acute myocardial infarction. MethodsWe retrospectively studied 246 female patients with acute myocardial infarction who were treated in General Hospital of PLA from January 2005 to January 2010, and they were divided into four groups according to whether menopause or not and the time after menopause. The cardiovascular risk factors were compared among the four groups. ResultsThere was no significant difference（P≥0.05）in the average level of body mass index, fibrinogen, total bilirubin and the rate of smoking, low hemoglobin between pre-menopausal and post-menopausal groups. There was no significant difference（P≥0.05）in the rate of hypertension and diabetes mellitus among pre-menopausal group, post-menopause within 5 years group and post-menopause from 5 to 10 years group. The rate of hypertension and diabetes mellitus was higher in post-menopause more than 10 years group than in any other groups, and there was statistical difference (P＜0.05). There was no significant difference（P≥0.05）in the average level of total cholesterol, triglyceride and LDL-C between pre-menopausal and post-menopausal groups. The average level of HDL-C was higher in pre-menopausal group than in any other post-menopausal groups, and there was statistical difference (P＜0.05). The rate of hyperuricemic patients in pre-menopausal group was lower than in any other post-menopausal groups, and there was statistical difference (P＜005). The rate of the patients with a family history of early-onset coronary heart disease in pre-menopausal group was higher than in any other post-menopausal groups, and there was statistically significant difference (P＜0.01). It was suggested that the years of menopause was relative to hyperuricemia (P=0.031，OR=0.767). ConclusionThere were differences in cardiovascular risk factors between pre-menopausal and post-menopausal female patients with acute myocardial infarction. The early prevention, diagnosis and treatment of female coronary heart disease basing on the clinical characteristics of different physiological stages should be pay great attention. |
| keywords:Myocardial infarction Female Menopause Risk factor |
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