| 慢性肾脏病不同时期血清CysC 、β2-MG的变化特点及其与Scr的相关性研究 |
| 投稿时间：2010-05-08 点此下载全文 |
| 引用本文：孙秀丽,陈爱珍.慢性肾脏病不同时期血清CysC 、β2-MG的变化特点及其与Scr的相关性研究[J].医学研究杂志,2011,40(3):104-107 |
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| 中文摘要:目的探讨慢性肾脏病（CKD）不同时期血清胱抑素C（cystatin C,CysC）和β2-微球蛋白（β2-MG）的变化特点及其与血肌酐（Scr）的相关性。方法根据肾小球滤过率(GFR)将研究对象分为CKD 1、2、3、4、5 期组, 测定不同肾功能时期CysC、β2-MG、Scr、尿素氮（BUN）水平，分别与CKD1期组比较并将各期CysC、β2-MG和Scr进行相关性分析。结果CKD2、3、4、5期组cystatin C、β2-MG与CKD1组比较有统计学意义（P<0.01）。而CKD3、4、5期组SCr、BUN与CKD1组比较才有统计学意义（P<0.01）。相关分析显示，385例患者血清cystatin C与SCr 之间呈正相关(r=0.85, P<0.01)，β2-MG与SCr 之间呈正相关(r=0.88, P<0.01)；除CKD2期组SCr与cystatin C 、β2-MG没有相关性外，其余各组SCr与cystatin C、β2-MG均有相关性。结论慢性肾脏病患者的血清cysattniC、β2-MG在CKD2期就明显升高，提示在轻度肾功能不全患者中，CysC、β2-MG的灵敏度要明显优于SCr；CysC、β2-MG比SCr能更及时、早期反映GFR的下降。 |
| 中文关键词:慢性肾脏病（CKD） cystatin C β2-微球蛋白 肾功能 |
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| Research on the Characteristic of the Change of Serum Cystatin C and Beta2-microglobulin Concentration in Different Stages of Chronic Kidney Disease and the Correlation with Serum Creatinine |
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| Abstract:ObjectiveTo investigate the characteristic of the change of serum cystatin C and beta2-microglobulin concentration in different stages of chronic kidney disease and to study the correlation with serum creatinine. MethodsAccording to glomerular filtration rate, patients were divided into five groups :1,2,3,4,5 stages of CKD groups. CysC，β2-MG，Scr and BUN of 385 CKD patients were detected .Above mentioned chemical examination indexes of CKD 2，3，4，5 stages were compared with CKD1 respectively. CysC and β2-MG of every CKD stage were processed by correlated analysis with Scr in accordingly CKD stages. ResultsThe level of serum cystatin C and β2-MG of CKD 2,3,4,5 stages had statistical significance compared to CKD1 stages（P<0.01）,while the level of Scr and BUN of CKD 3,4,5 stages had statisticcal significance compared to CKD1 stages（P<0.01）. The level of serum cystatin C was positively correlated with SCr (r=0.85,P<0.01)and the level of β2-MG was also positively correlated with SCr (r=0.88,P<0.01 ). Except CKD2 stage，the level of serum cystatin C and beta2-microglobulin was positively correlated with SCr in other CKD stages. ConclusionSerum cystatin C and β2-MG concentration of chronic kidney disease obviously increased in CKD2 stage,which indicated that the sensitivity of cystatin C and β2-MG was better than serum creatinine and they could reflect the decrease of GFR earlier than serum creatinine in mild renal inadequacy patients. |
| keywords:CKD Cystatin C β2-microglobulin Renal function |
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