| HGF和MMP-9在扁平苔藓皮损中的表达及意义 |
| 投稿时间：2010-09-16 点此下载全文 |
| 引用本文：何肖,白莉.HGF和MMP-9在扁平苔藓皮损中的表达及意义[J].医学研究杂志,2011,40(3):123-124 |
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| 中文摘要:目的检测扁平苔藓皮损中肝细胞生长因子（HGF）和基质金属蛋白酶-9（MMP-9）的表达情况，探讨其在扁平苔藓发病中的意义。方法应用免疫组化法和RT-PCR法测定30例扁平苔藓及30例正常皮肤组织中HGF和MMP-9的表达水平。结果扁平苔藓组中HGF和MMP-9的表达率均高于正常对照组（P<0.01），且二者在扁平苔藓皮损中的表达呈正相关（r1=0.391,P1=0.032;r2=0.375,P2=0.041）。结论HGF和MMP-9的高表达可能参与了扁平苔藓的发病。 |
| 中文关键词:扁平苔藓 肝细胞生长因子 基质金属蛋白酶-9 |
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| The Expression and Significance of HGF and MMP-9 in Lichen Planus |
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| Abstract:ObjectiveTo explore the expression of hepatocyte growth factor(HGF) and metalloproteinase-9(MMP-9) in lichen planus，and investigate the function in pathogenesis of lichen planus. MethodsThe expression of HGF and MMP-9 was assayed by RT-PCR and immunohistochemistry in 30 LP lesions and 30 normal skins. ResultsThe expression of HGF and MMP-9 in LP lesions was stronger than that in normal skins（P<0.01）,and HGF was positively related to the expression of MMP-9 in LP lesions （r1=0.391,P1=0.032; r2=0.375, P2=0.041）.ConclusionThe increased expression of HGF and MMP-9 may contribute to the formation and progression of lichen planus. |
| keywords:Lichen planus Hepatocyte growth factor Metalloproteinase-9 |
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