| 羟考酮控释片用于滴定中度癌痛的疗效观察 |
| 投稿时间：2010-10-18 修订日期：2011-02-20 点此下载全文 |
| 引用本文：张颖一,韩廷,汪颖,刘璐,王宁,王雅杰.羟考酮控释片用于滴定中度癌痛的疗效观察[J].医学研究杂志,2011,40(4):52-54 |
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| 基金项目:上海市重点学科建设项目资助（B905） |
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| 中文摘要:目的评价盐酸羟考酮控释片对中度癌性疼痛滴定期的疗效优势。方法本研究选取67例无阿片类药物使用史的中度癌痛患者，随机分为两组，A组（35例）使用盐酸羟考酮控释片5mg作为初始剂量对其进行滴定，B组（32例）使用硫酸吗啡控释片10mg滴定，达到疼痛明显缓解或完全缓解后进入维持期。观察期4天，以服药后1h的NRS评分(numerical rating scale，数字模拟评分法)为主要观察指标，将两组疗效进行对比。结果给药1h后盐酸羟考酮控释片组中有1例患者疼痛获得完全缓解，12例症状明显缓解，11例达到中度缓解，总有效率高达68.6％ ；硫酸吗啡控释片组有4例获得明显缓解，10例疼痛中度缓解，总有效率43.8% 。服药第4天两组患者疼痛总缓解率均在90%左右。结论在迅速缓解疼痛方面，盐酸羟考酮控释片组具有优势；而在维持期控制疼痛方面，两组疗效相当。 |
| 中文关键词:盐酸羟考酮控释片 硫酸吗啡控释片 剂量滴定 癌症 中度疼痛 |
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| Effect of the Titration of Oxycodone Controlled-release Tablets on Moderate Pain |
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| Abstract:ObjectiveTo evaluate the efficacy advantage of oxycodone hydrochloride controlled-release tablets for moderate cancer pain. MethodsThis study selected 67 patients suffering from moderate pain without a history of opioid. They were randomly divided into 2 groups. A group (35 cases) used the oxycodone hydrochloride controlled-release tablets 5mg as the initial dose for titration,and B group (32 cases) used the morphine sulfate controlled-release tablets 10mg. All of them entered the maintenance phase after been titrated to achieve obvious relief or complete relief of pain. Within 4-day observation period, we got the NRS score (Numerical Rating Scale, digital analog scale) ［2］ the first hour after taking the pills as the main observation index to compare the two groups. ResultsIn the group of oxycodone hydrochloride controlled-release tablets, 1 patient achieved complete relief after 1 hour administration, 12 were obviously relieved, and 11 were moderate relieved. The total efficiency was up to 68.6%. At the same time, in the group of morphine sulfate controlled-release tablets, 4 patients were obviously relieved, 10 got moderate relief,and the total effective was 43.8%. The total pain relief rate of both two group were at 90% on the 4th day. ConclusionOxycodone hydrochloride controlled-release tablets group has advantages in rapid pain relief.In the terms of maintenance of pain control, the two groups has the similar effects. |
| keywords:Oxycodone hydrochloride controlled release tablets Morphine sulfate controlled-releast tablets Dose titration Cancer Moderate pain |
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