羟考酮控释片用于滴定中度癌痛的疗效观察
投稿时间:2010-10-18  修订日期:2011-02-20  点此下载全文
引用本文:张颖一,韩廷,汪颖,刘璐,王宁,王雅杰.羟考酮控释片用于滴定中度癌痛的疗效观察[J].医学研究杂志,2011,40(4):52-54
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作者单位
张颖一 第二军医大学附属长海医院 
韩廷 第二军医大学附属长海医院 
汪颖 第二军医大学附属长海医院 
刘璐 第二军医大学附属长海医院 
王宁 第二军医大学附属长海医院 
王雅杰 第二军医大学附属长海医院 
基金项目:上海市重点学科建设项目资助(B905)
中文摘要:目的评价盐酸羟考酮控释片对中度癌性疼痛滴定期的疗效优势。方法本研究选取67例无阿片类药物使用史的中度癌痛患者,随机分为两组,A组(35例)使用盐酸羟考酮控释片5mg作为初始剂量对其进行滴定,B组(32例)使用硫酸吗啡控释片10mg滴定,达到疼痛明显缓解或完全缓解后进入维持期。观察期4天,以服药后1h的NRS评分(numerical rating scale,数字模拟评分法)为主要观察指标,将两组疗效进行对比。结果给药1h后盐酸羟考酮控释片组中有1例患者疼痛获得完全缓解,12例症状明显缓解,11例达到中度缓解,总有效率高达68.6% ;硫酸吗啡控释片组有4例获得明显缓解,10例疼痛中度缓解,总有效率43.8% 。服药第4天两组患者疼痛总缓解率均在90%左右。结论在迅速缓解疼痛方面,盐酸羟考酮控释片组具有优势;而在维持期控制疼痛方面,两组疗效相当。
中文关键词:盐酸羟考酮控释片  硫酸吗啡控释片  剂量滴定  癌症  中度疼痛
 
Effect of the Titration of Oxycodone Controlled-release Tablets on Moderate Pain
Abstract:ObjectiveTo evaluate the efficacy advantage of oxycodone hydrochloride controlled-release tablets for moderate cancer pain. MethodsThis study selected 67 patients suffering from moderate pain without a history of opioid. They were randomly divided into 2 groups. A group (35 cases) used the oxycodone hydrochloride controlled-release tablets 5mg as the initial dose for titration,and B group (32 cases) used the morphine sulfate controlled-release tablets 10mg. All of them entered the maintenance phase after been titrated to achieve obvious relief or complete relief of pain. Within 4-day observation period, we got the NRS score (Numerical Rating Scale, digital analog scale) [2] the first hour after taking the pills as the main observation index to compare the two groups. ResultsIn the group of oxycodone hydrochloride controlled-release tablets, 1 patient achieved complete relief after 1 hour administration, 12 were obviously relieved, and 11 were moderate relieved. The total efficiency was up to 68.6%. At the same time, in the group of morphine sulfate controlled-release tablets, 4 patients were obviously relieved, 10 got moderate relief,and the total effective was 43.8%. The total pain relief rate of both two group were at 90% on the 4th day. ConclusionOxycodone hydrochloride controlled-release tablets group has advantages in rapid pain relief.In the terms of maintenance of pain control, the two groups has the similar effects.
keywords:Oxycodone hydrochloride controlled release tablets  Morphine sulfate controlled-releast tablets  Dose titration  Cancer  Moderate pain
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