| 肝细胞癌组织中HLA-DR,-DQ的表达及其意义 |
| 投稿时间：2010-11-15 修订日期：2011-03-02 点此下载全文 |
| 引用本文：李宏涛,肖文华,李秋文,郝怡鑫,朱建华,王如良,叶明.肝细胞癌组织中HLA-DR,-DQ的表达及其意义[J].医学研究杂志,2011,40(5):26-28 |
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| 基金项目:国家自然科学基金资助项目(30572144) |
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| 中文摘要:目的探讨人白细胞抗原（HLA）-DR和-DQ分子在肝细胞癌的表达及其意义。方法采用免疫组化法分别检测HLA-DR和HLA-DQ抗原在38例人肝癌组织芯片中的表达情况，并和临床病理资料进行相关性分析。结果肝癌组织中HLA-DR和HLA-DQ抗原信号主要定位于细胞浆。HLA-DR的阳性率为5.3％（2/38），HLA-DQ的阳性率为92.1%(35/38)，但在4例伴淋巴结转移的肝癌中，3例无HLA-DQ的表达， HLA-DQ表达与肝癌的淋巴结转移负相关（P＜0.0001）。HLA-DR和HLA-DQ表达与年龄和肝癌的组织分化无相关性（P＞0.05）。结论HLA-DQ的表达在肝癌组织中很常见，无HLA-DQ的表达可能提示与淋巴结转移有关。 |
| 中文关键词:HLA-DR HLA-DQ 肝癌 免疫组织化学 |
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| Expression of HLA-DR and HLA-DQ in Hepatocellular Carcinoma and its Significance |
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| Abstract:ObjectiveTo study the expression of HLA-DR and HLA-DQ antigens in hepatocellular carcinoma(HCC) and its significance. MethodsThe expression of HLA-DR and HLA-DQ antigens in human 38 HCCs cases were detected with immunohistochemistry, then the relations between the expression of genes with clinical and pathology parameters (such as cancerous differentiation and metastasis and others)were analyzed by Chi square test.ResultsThe immunoreactivity of HLA-DR and -DQ proteins were mainly distributed in cytoplasm of cancerous cells, the positive rate of HLA-DR and DQ expression were 5.3%(2/35) and 92.1%(35/38) respectively. HLA-DR was related with gender of HCC patients, HLA-DQ was positive relation with non-lymphatic metastasis of HCC (P<0.0001).ConclusionHLA-DQ expression is very common in HCCs; The absence of HLA-DQ expression may contribute to lymphnodes metastasis in HCC. |
| keywords:HLA-DR HLA-DQ Hepatocellular carcinoma Immunohistochemistry |
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