| 2型糖尿病合并血管性轻度认知功能障碍患者血浆同型半胱氨酸浓度的研究 |
| 投稿时间：2010-09-24 点此下载全文 |
| 引用本文：李颖,杜晓红,王川怡,赵晓薇,余华.2型糖尿病合并血管性轻度认知功能障碍患者血浆同型半胱氨酸浓度的研究[J].医学研究杂志,2011,40(5):86-88 |
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| 中文摘要:目的探讨2型糖尿病合并血管性轻度认知功能障碍与高同型半胱氨酸血症的关系。方法选取45例糖尿病合并血管性轻度认知障碍患者、30例糖尿病患者及30例健康对照者，分别测定同型半胱氨酸、空腹血糖、空腹胰岛素、糖化血红蛋白、三酰甘油、总胆固醇及低密度脂蛋白胆固醇水平，计算胰岛素敏感指数。结果①单纯糖尿病组和糖尿病合并认知障碍组Hcy、FBG、FIN、ISI、HbA1c水平均高于对照组，且合并认知障碍组Hcy、FIN、ISI、HbA1c水平较单纯糖尿病组更高;②多因素回归分析显示HbA1c、Hcy、ISI与糖尿病并发血管性轻度认知功能障碍有关。结论高同型半胱氨酸是2型糖尿病合并血管性轻度认知障碍发生的独立危险因素，可能在糖尿病合并认知障碍的发生、发展过程中起到一定作用。 |
| 中文关键词:糖尿病2型 认知障碍 同型半胱氨酸 |
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| Hyperhomocysteinemia in Type 2 Diabetes Mellitus with Vascular Mild Cognitive Impairment |
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| Abstract:ObjectiveTo explore the significance of hyperhomocysteinemia in type 2 diabetes mellitus (DM) with vascular mild cognitive impairment (VMCI). MethodsWe selected 45 patients with type 2 DM and VMCI, 30 patients with type 2 DM,and 30 healthy controls. Plasma homocysteine (Hcy), fasting blood sugar (FBG), fasting insulin (FIN), hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) levels were measured. ResultsThe plasma levels of Hcy,FBG,FIN,ISI and HbA1c in DM group and DM with VMCI group were significantly higher than those in control group, and the levels of Hcy,FIN,ISI,HbA1c were even higher in DM with VMCI group. Logistic regression analysis indicated that HbA1c,Hcy and ISI were related to DM with VMCI. ConclusionHyperhomocysteinemia was the independent risk factor for DM with VMCI. Hcy may be involved in the pathogenesis and development of cognitive impairment in type 2 DM. |
| keywords:Type 2 diabetes mellitus Cognitive impairment Homocysteine |
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