| 持续气道内正压通气治疗男性阻塞性睡眠呼吸暂停低通气综合征患者性功能障碍作用的研究 |
| 投稿时间：2010-07-11 点此下载全文 |
| 引用本文：李国平,王良兴,许雯,姜琴华,蒋海波.持续气道内正压通气治疗男性阻塞性睡眠呼吸暂停低通气综合征患者性功能障碍作用的研究[J].医学研究杂志,2011,40(5):99-102 |
| DOI：
|
| 摘要点击次数: 1377 |
| 全文下载次数: 1296 |
|
|
| 中文摘要:目的研究持续气道内正压通气（CPAP）对男性阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并勃起功能障碍（ED）患者的疗效及可能机制。方法经多导睡眠监测仪（PSG）及同步夜间阴茎勃起（NPT）测定，诊断OSAHS合并ED患者48名，其中25名给予CPAP治疗作为CPAP组；未经CPAP治疗的23名患者作为OSAHS组，选取健康成年男性28名为健康对照组。结果三组之间的性激素水平（PRL、TT、E2、FSH、LH）差异无统计学意义（P＞0.05），但CPAP组、OSAHS组的NO、NOS、LSaO2及阴茎血容积变化率较健康对照组降低（P＜0.05），且CPAP治疗后NO、NOS、LSaO2及阴茎血容积变化率不同程度升高，而AHI下降（P＜0.05）。结论CPAP治疗可提高OSAHS患者血浆NO、NOS水平，从而改善OSAHS的性功能。 |
| 中文关键词:持续气道正压通气 阻塞性睡眠呼吸暂停低通气综合征 性功能障碍 一氧化氮 |
| |
| The Effect of Continuous Positive Airway Pressure on the Erectile Function of Patients with Obstructive Sleep Apnea Hypopnea Syndrome with Erectile Dysfunction and Research of the Related Mechanism |
|
|
| Abstract:ObjectiveTo study the effect of continuous positive airway pressure in patient with obstructive sleep apnea hypopnea syndrome with erectile dysfunction and the related mechanism.MethodsThere were 48 patients diagnosed with OSAHS and ED by polysomnography and nocturnal penile tumescence. The 25 patients with treatment of 6-months′ CPAP were designated to CPAP group，and other non-CPAP 23 patients were designated to OSAHS group. Otherwise, twenty-eight normal adult male were assigned as healthy control group. ResultsThe sex hormones levels of three groups had no significant change(P>0.05). When the CPAP and OSAHS group compared with healthy control, the level of NO，NOS，LSaO2 and percentage of penile blood volume change were significantly lower (P<0.05). All indexes were significantly higher in the CPAP group after therapy, but AHI was lower (P<0.05). ConclusionCPAP therapy can raise the level of NO and NOS, and significantly improve the sexual function of the patients with OSAHS. |
| keywords:Continuous positive airway pressure Obstructive sleep apnea hypopnea syndrome Sexual dysfunction Nitrogen monoxide |
| 查看全文 查看/发表评论 下载PDF阅读器 |
