| 甲状腺髓样癌的临床病理及治疗分析 |
| 投稿时间：2010-07-29 修订日期：2011-02-28 点此下载全文 |
| 引用本文：李俊霖,韩少良,谢建锋,周长虹,唐夏玉,郭圣聪,李旺勇.甲状腺髓样癌的临床病理及治疗分析[J].医学研究杂志,2011,40(5):117-118 |
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| 中文摘要:目的探讨甲状腺髓样癌的诊断及临床病理特征，比较不同手术方法对患者预后的影响。方法回顾性分析1999年3月~2008年3月笔者医院收治的19例甲状腺髓样癌的诊治资料。结果19例患者经术前B超检查提示甲状腺肿物伴钙化6例，伴有淋巴结转移10例。手术方式包括甲状腺全切术3例，患侧甲状腺叶切除+峡部+对侧部分切除12例，患侧甲状腺叶次全或部分切除4例；双侧颈部淋巴结清扫3例，患侧颈部淋巴结清扫11例，颈部淋巴结未清扫5例。除失访2例外，其余17例患者均存活，无肿瘤复发转移。结论甲状腺髓样癌术前诊断较困难，确诊主要依赖病理组织检查，治疗首选外科手术，手术切除范围及淋巴结清除程度应病变具体浸润情况决定，适度缩小的淋巴结清扫范围不增加肿瘤复发转移。 |
| 中文关键词:甲状腺髓样癌 手术治疗 淋巴结清扫 |
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| Clinicopathological Characteristics and Outcome Analysis of Medullary Thyroid Carcinoma |
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| Abstract:ObjectiveTo investigate the diagnosis and clinicopathological characteristics of medullary thyroid carcinoma, and to access the effect of the different surgical procedures on prognosis. MethodsThe medical data of the patients with medullary thyroid carcinoma in our hospital from March 1999 to March 2008 were analyzed retrospectively.ResultsPreoperative ultrasonography showed that thyroid nodule associated calcifications in 6 patients, and associated with lymph nodes metastasis in 10 patients. All these patients underwent operations, included total thyroidectomy in 3 patients, ipsilateral total lobectomy+ isthmic resection+contralateral partial lobectomy in 12 patients,ipsilateral subtotal or partial lobectomy in 4 patients, bilateral neck dissection in 3 patients, ipsilateral neck dissection in 11 patients, and no neck dissection in 5 patients. Except 2 cases failed to follow up, the others 17 patients were alive, without evidence of tumor recurrence and metastasis.ConclusionIt is difficult to diagnosis the medullary thyroid carcinoma before operation, and diagnosis mainly depended on the pathological examination. The surgical procedure is the choice of treatment. The removal extent and neck lymph node dissection is determined according to the extent of disease, and properly limited operation does not increase the risk of tumor recurrence and metastasis. |
| keywords:Medullary thyroid carcinoma Surgical treatment Lymph node dissection |
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