| 前列腺癌患者血清VEGF和PSA的检测及临床价值 |
| 投稿时间：2010-10-18 修订日期：2011-03-22 点此下载全文 |
| 引用本文：马伟刚,王兴木.前列腺癌患者血清VEGF和PSA的检测及临床价值[J].医学研究杂志,2011,40(5):134-137 |
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| 中文摘要:目的探讨血清血管内皮生长因子(VEGF)和前列腺特异性抗原(PSA)在前列腺癌(PCA)诊断、转移和预后中的应用价值。方法应用ELISA 法检测89例 PCA、45例前列腺增生(BPH)和30例正常人群血清VEGF的浓度，并将三者进行对照分析。结果PCA组患者血清VEGF、t-PSA、f-PSA浓度显著高于BPH组、正常对照组 (P<0.05)；PCA组患者f/t PSA比值显著低于BPH组、正常对照组 (P<0.05) ；BPH组患者血清t-PSA、f-PSA浓度显著高于正常对照组 (P<0.05)；BPH组患者与正常对照组比较，VEGF、f/t PSA比值差异不具有统计学意义(P>0.05)；PCA高、中、低分化组间血清VEGF、t-PSA、f-PSA比较差异均有统计学意义(P<0.05)；C+D期PCA 血清VEGF、t-PSA、f-PSA表达显著高于A+B期（P<0.05）；淋巴结转移阳性组血清VEGF、t-PSA、f-PSA水平显著高于阴性组（P<0.05）。前列腺癌患者血清f/t PSA比值与分化分级、临床分期和淋巴结转移无明显相关性(P>0.05)。结论血清VEGF、PSA 的检测有助于PCA 的诊断；血清VEGF、PSA浓度水平与前列腺癌的分化分级、临床分期和浸润转移相关，其检测对PCA术前病情判断、疗效和预后评价有一定的临床意义。 |
| 中文关键词:前列腺癌 血管内皮生长因子 前列腺特异性抗原 |
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| The Clinical Value of Detection of VEGF and PSA in Serum of the Patients with Prostatic Carcinoma |
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| Abstract:ObjectiveTo detect vascular endothelial growth factor (VEGF), prostate specific antigen (PSA) expression in the patients with prostatic carcinoma and to evaluate their value in diagnosis, metastasis and prognosis. MethodsELISA method was aoloped to detect serum VEGF concentration in the sera of 89 prostatic carcinoma (PCA) patients cases, 45 benign prostatic hyperplasia (BPH) patients cases and 30 controls.ARCHITECT i2000SR immunoassay was applied to detect serum PSA concentration. The results were statistically analyzed. ResultsSerum VEGF, t-PSA, f-PSA expression were significantly higher in the patients with PCA than those with BPH and the controls(Ｐ<0.05). Serum f/t PSA was significantly lower in the patients with PCA than those with BPH and the controls(Ｐ<0.05). Serum t-PSA,f-PSA were significantly higher in the patients with BPH than the controls(Ｐ<0.05). And the difference of VEGF,f/t PSA between patients in BPH group and the controls was not statistically significant (P>0.05). The differences of VEGF,t-PSA,f-PSA among well-differentiated, moderately differentiated, poorly differentiated patients were statistically significant(Ｐ<005). Serum VEGF，t-PSA，f-PSA expression were significantly higher in the patients with C+D stage of PCA than those with A+B stage (Ｐ<0.05). Serum VEGF，t-PSA，f-PSA expression were significantly higher in the patients with lymph node metastasis than those without lymph node metastasis (Ｐ<0.05). Serum f/t PSA had no significant correlation with differentiated, clinical stage and metastasis (P>0.05). ConclusionTo detect VEGF,PSA expression was helpful for PCA diagnosis. Serum VEGF, PSA (f/t PSA excluded) expression had something to do with differentiation, clinical stage and metastasis. It may be useful to preoperative evaluation, curative effect and prognosis. |
| keywords:Prostatic carcinoma Vascular endothelial growth factor Prostate specific antigen |
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