| 白三烯受体基因多态性与孟鲁司特治疗反应性关系的研究 |
| 投稿时间：2010-12-01 修订日期：2011-03-17 点此下载全文 |
| 引用本文：宣妙燕,蔡晓红,李宁,俞晨艺,陈小剑,陈新宇,曹顺顺,李秀翠.白三烯受体基因多态性与孟鲁司特治疗反应性关系的研究[J].医学研究杂志,2011,40(6):45-48 |
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| 基金项目:浙江省人口和计划生育科技项目;浙江省医学会临床科研基金(2008ZYC26) |
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| 中文摘要:目的评价哮喘患儿半胱氨酰白三烯受体1(CysLTR1)927 T/C位点基因多态性对白三烯受体拮抗剂治疗的反应性。方法选择2007年4月～2008年11月在笔者医院门诊就诊的哮喘患儿86例。用DNA直接测序法测定CysLTR1 927 T/C位点的基因型，根据基因型将其分为TT、CT、CC 3组，予白三烯受体拮抗剂（LTRA）孟鲁司特治疗6个月。观察3组患儿过敏性鼻炎和临床症状的控制情况，监测治疗前后血清总免疫球蛋白E（TIgE）、尘螨免疫球蛋白（D1IgE）和肺功能的变化。结果3组基因型患儿过敏性鼻炎和临床症状的控制情况比较无明显差异（P>0.05），患儿治疗前后TIgE、D1IgE和肺功能第一秒用力呼气容积（FEV1）、呼气峰流速（PEF）的改善，3组比较亦无差异，P均>0.05。结论本研究表明，温州地区汉族哮喘患儿CysLTR1 927 T/C位点基因多态性与白三烯受体拮抗剂治疗的反应性无关。 |
| 中文关键词:白三烯受体拮抗剂 基因多态性 哮喘 儿童 |
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| The Relationship between Polymorphisms of CYSLTR1 and Therapeutic Efficacy of Montelukast |
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| Abstract:ObjectiveTo estimate if there is different reaction in three genetypes of CYSLTR1 927T/C in the children with asthma who took leukotriene receptor antagonist (LTRA) montelukast. MethodsEighth-six children with asthma admitted to the out-patient clinic of the Affiliated Yuying Children′s Hospital to Wenzhou Medical College from Aprily2007 to November 2008 were analyzed. Sequence analysis was used for detecting the gene polymorphism of 927T/C of the CYSLTR1 in 86 patients,and we divided patients into three genetype groups of TT,CT and CC.These patients took leukotriene receptor antagonist (LTRA) montelukast for six months. Children in the three genetype groups were monitored for clinical symptom control and allergic rhinitis during the stage of therapy.Total serum immune globulin E(TIgE),dust mite immune globulin E (D1IgE),lung function prior and post-treatment were recorded. ResultsThere was no difference found among the three genetype groups in clinical symptom control and allergic rhinitis, either in the improvement in TIgE,D1IgE,lung function such as forced expiratory volume in 1 second (FEV1)and peak expiratory flow(PEF) prior and post-treatment,with all P>0.05. ConclusionThe gene polymorphism of 927T/C of the CYSLTR1 has no relationship with the rapeutic efficacy of the children with asthma of Chinese Han people in Wenzhou Ctiy who took leukotriene receptor antagonist (LTRA). |
| keywords:Leukotriene receptor antagonist Gene polymorphism Asthma Children |
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