| 慢性乙型肝炎患者、乙型肝炎肝硬化患者外周血CD4+CD25+调节性T细胞的水平及意义 |
| 投稿时间：2010-12-16 点此下载全文 |
| 引用本文：张磊,谷甸娜,陈永平,郑明华.慢性乙型肝炎患者、乙型肝炎肝硬化患者外周血CD4+CD25+调节性T细胞的水平及意义[J].医学研究杂志,2011,40(7):60-62 |
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| 基金项目:浙江省自然科学基金资助项目（Y207464）；浙江省科技厅新苗人才计划项目（2008R40G2090022） |
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| 中文摘要:目的测定慢性乙型肝炎患者、乙型肝炎肝硬化患者外周血CD4+CD25+调节性T细胞(Treg)的水平并探讨其意义。方法流式细胞术检测12例慢性乙型病毒性肝炎患者，15例乙型病毒性肝炎后肝硬化患者和6例健康对照者外周血中CD4+CD25+ Treg 的频率。结果12例慢性乙型病毒性肝炎患者外周血中CD4+CD25+Treg 占CD4+淋巴细胞的比例为(12.21±1.46)%, 15例慢性乙型病毒性肝炎后肝硬化患者外周血中CD4+CD25+ Treg占CD4+淋巴细胞的比例为(11.36±106)%，与6例健康对照组(9.86±1.00)%相比差异有显著性(P<0.05)，慢性乙型病毒性肝炎与慢性乙型病毒性肝炎后肝硬化组间比较差异无显著性(P>0.05)。结论Treg与CHB患者持续HBV感染密切相关，而是否参与乙肝后肝硬化的发病机制有待进一步研究。 |
| 中文关键词:CD4+CD25+调节性T细胞 慢性乙型病毒性肝炎 肝硬化 |
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| Abstract:ObjectiveTo analyze the level of CD4+CD25+ regulatory T cells(Treg)in peripheral blood of chronic HBV and HBV-related liver cirrhosis patients and study its clinical significance. Methods12 CHB patients，15 HBV-related liver cirrhosis patients and 6 healthy controls were enrolled in the study.The flow cytometry was used to detect the frequency of CD4+CD25+ Tregs in the peripheral blood. ResultsThe frequency of CD4+CD25+ Tregs in the peripheral blood in the CHB and cirrhosis were (12.21±1.46)% and (1136±1.06)% respectively，which were both higher than those(9.86±1.00)% of the controls(P<0.05).There was no significant difference betwwen the CHB and cirrhosis(P>0.05). ConclusionThese findings suggest that CD4+CD25+ Treg plays an role in the persistent infection of HBV,but is not sure in the mechanism of HBV-related liver cirrhosis. |
| keywords:CD4+CD25+ regulatory T cells Chronic hepatitis B Liver cirrhosis |
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