| 肺癌患者血浆组织因子与血小板参数及其活化标志物的临床意义 |
| 投稿时间：2010-12-24 点此下载全文 |
| 引用本文：胡文健,陈秉宇,费鲜明.肺癌患者血浆组织因子与血小板参数及其活化标志物的临床意义[J].医学研究杂志,2011,40(7):98-100 |
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| 中文摘要:目的评价血浆组织因子、血小板参数及血小板活化标志物检测在肺癌中的应用价值，并探讨它们之间的关系。方法分别检测97例肺癌患者、22例良性肺部疾病患者以及25例正常对照者血浆组织因子（TF），全血血小板计数（CPC）、平均血小板体积（MPV）和血小板分布宽度（PDW）以及血小板最大聚集率（PAR）和血小板-单核细胞聚集物（PMA）水平，并计算各指标的阳性率（%）。结果肺癌组TF、CPC、MPV、PDW、PAR及PMA水平均显著高于正常对照组和良性肺疾病组（P<0001）。肺癌TNM分期Ⅲ期和Ⅳ期患者各指标水平均显著高于Ⅰ期和Ⅱ期患者，Ⅳ期患者TF、PAR及PMA水平显著高于Ⅲ期患者（P<0.001）。不同组织类型和不同分化程度肺癌的各指标水平差异均无统计学意义（P>0.05）。 TF、PMA和PAR的阳性率分别为100.0%、92.8%和87.6%，均显著高于CPC、MPV和PDW的70.1%、76.3%和78.4%（P均<0.05）。TF与CPC、MPV、PDW、PAR及PMA均呈显著正相关（P均<0.05），与PAR和PMA的相关性均显著高于与CPC、MPV和PDW的相关性（P均<0.01）。结论肺癌患者检测血浆组织因子、血小板参数及血小板活化标志物具有重要的临床价值。组织因子和活化血小板水平在肺癌转移、血栓形成的判断以及患者病情评价中都具有重要意义。 |
| 中文关键词:肺癌 组织因子 血小板参数 活化血小板 |
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| Abstract:ObjectiveTo evaluate the application value of plasma tissue factor, platelet parameters and platelet activation markers in patients with lung cancer, and to explore the correlation one another. MethodsSamples from 97 patients with lung cancer, 22 patients with benign lung disease and 25 healthy controls were determined for the levels of plasma tissue factor (TF), complete platelet count(CPC), mean platelet volume (MPV), platelet distribution width (PDW), maximal platelet aggregation rate (PAR) and platelet-moncyte aggregate (PMA). And the positive percent was calculated, respectively. ResultsIn lung cancer group, the level of TF, CPC, MPV, PDW, PAR and PMA, respectively, was notably higher than those in either healthy control group or benign lung disease group（P<0.001）. The levels of the six indicators at TNM-stage Ⅲ and Ⅳ were remarkedly higher than those at stage Ⅰ and Ⅱ in lung cancer patients, and the levels of TF, PAR as well as PMA at TNM-stage Ⅳ were markedly higher than those at stage Ⅲ（P<0.001）.There was no statistical difference between the levels of the six indicators one another in lung cancer of different histology and differential status（P>0.05）.The positive percent of TF, PMA and PAR (100.0%, 92.8% and 87.6%), respectively, was significantly higher that of CPC, MPV and PDW(70.1%, 76.3% and 78.4%), respectively（P<0.05）. There was positive correlation between TF and either CPC, MPV, RDW, PAR or PMA（P<0.05）, and the correlation between TF and PAR as well as PMA was much doser than that between TF and CPC, MPV as well as PDW (P<0.01）. ConclusionsIt is useful to measure plasma tissue factor, platelet parameters and platelet activation markers in patients with lung cancer. The tissue factor and activated platelet are more important indicators in the judgement of lung cancer metastasis and hemostasis as well as the evaluation of disease status. |
| keywords:Lung cancer Tissue factor Platelet parameters Activated platelet |
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