| 2型糖尿病患者糖化血红蛋白和超敏C反应蛋白在微血管病变中的临床价值 |
| 投稿时间：2010-11-25 点此下载全文 |
| 引用本文：钟淑萍,王兴木.2型糖尿病患者糖化血红蛋白和超敏C反应蛋白在微血管病变中的临床价值[J].医学研究杂志,2011,40(7):122-125 |
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| 中文摘要:目的探讨糖化血红蛋白(HbA1c)和超敏C反应蛋白(hs-CRP)在糖尿病微血管病变中的临床价值。方法采用生化分析仪测定172例2型糖尿病病史超过10 年的患者［其中41例未发生微血管病变(NDMA)，131例存在微血管病变(DMA)］和50例健康对照］糖化血红蛋白和超敏C反应蛋白(hs-CRP)。结果2型糖尿病患者外周血中HbA1c、hs-CRP浓度均显著高于健康对照组 (Ｐ<0.05)； DMA组患者外周血中HbA1c、hs-CRP浓度显著高于NDMA组 (Ｐ<0.05)；糖尿病肾病(DN)兼有糖尿病视网膜病变(DR)组患者外周血HbA1c、hs-CRP的浓度高于DN组、 DR组 (Ｐ<0.05)；DN组外周血HbA1c、hs-CRP的浓度与DR组患者的浓度差异无统计学意义(Ｐ>0.05)；外周血HbA1c检测用于诊断DMA具有较高的敏感性(939%)、阳性预测值(83.7%)、阴性预测值(68.0%)、可靠性(81.4%)；hs-CRP检测用于诊断DMA具有较高的特异性(976%)，阳性预测值(97.6%)。结论外周血中HbA1c、hs- CRP检测有助于2型糖尿病以及糖尿病微血管病变的诊断；HbA1c、hs- CRP浓度与糖尿病微血管病变的进展相关。 |
| 中文关键词:2型糖尿病 糖化血红蛋白 超敏C反应蛋白 糖尿病微血管病变 |
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| Abstract:ObjectiveTo discuss the clinical value of glycosylated hemoglobin and high sensitivity C-reactive protein in microangiopathy of type 2 diabete.MethodsAnalysator was applied to detect peripheral blood glycosylated hemoglobin and high sensitivity C-reactive protein of the 172 patients with type 2 diabete more 10 years and 50 controls.ResultsPeripheral blood glycosylated hemoglobin and high sensitivity C-reactive protein of the patients with type 2 diabete were significantly higher than the controls(P<0.05).Peripheral blood glycosylated hemoglobin and high sensitivity C-reactive protein of the patients with diabetic microangiopathy were significantly higher than the NDMA (P<0.05). Peripheral blood glycosylated hemoglobin and high sensitivity C-reactive protein of the patients with diabetic nephropathy and diabetic retinopathy were significantly higher than those with only one symptom (P<0.05), but the difference in peripheral blood glycosylated hemoglobin and high sensitivity C-reactive protein between diabetic nephropathy group and the diabetic retinopathy group was not statistically significant (P>0.05).For peripheral blood glycosylated hemoglobin to diagnose DMA, the sensibility was 93.9%, the positive predictive value was 83.7%, negative predictive value was 68.0%, the reliability was 81.4%.For peripheral blood high sensitivity C-reactive protein to diagnose DMA, the specificity was 97.6%，the positive predictive value was 97.6%.ConclusionTo detect peripheral blood glycosylated hemoglobin and high sensitivity C-reactive protein was helpful for the diagnosis of type 2 diabete and diabetic microangiopathy.HbA1c, hs-CRP levels were associated with the progress of diabetic microvascular disease. |
| keywords:Type 2 diabete Glycosylated hemoglobin High sensitivity C-reactive protein Diabetic microangiopathy |
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