| 频发性室性期前收缩对扩张型心肌病患者炎症状态和心功能的影响 |
| 投稿时间：2011-01-05 修订日期：2011-05-30 点此下载全文 |
| 引用本文：石少波,杨波,梁锦军,李鹏飞,刘凯,王欣欣.频发性室性期前收缩对扩张型心肌病患者炎症状态和心功能的影响[J].医学研究杂志,2011,40(8):67-69 |
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| 基金项目:湖北省“十一五”重大科技攻关项目（2006A301A04）；湖北省自然科学基金优秀群体项目（2007ABC011）；武汉大学“中央高校基本科研业务费专项资金” 资助项目（4104006） |
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| 中文摘要:目的探讨频发性室性期前收缩（PVCs）对扩张型心肌病（DCM）患者炎症状态和心功能的影响。方法将188例DCM患者分为DCM+ PVCs组（128例）以及DCM组（60例），比较两组患者的hs-CRP水平，NYHA心功能分级， N端脑钠肽前体(NT-proBNP)水平 ，左心室舒张末内径(LVEDD)，左心室射血分数(LVEF)的差异。结果DCM+ PVCs组hs-CRP水平(4.21±2.39mg/L)，DCM组(3.75±2.25mg/L)，两组hs-CRP水平比较无统计学差异（P>0.05) ；DCM+ PVCs组与DCM组相比，NYHA分级更高（3.02±0.62级vs 2.68±0.66级，P<0.05），NT-proBNP浓度≥1800pg/ml 者更多（105/128 vs 37/60，P<0.01），LVEDD更大（65.65±7.82mm vs 59.63±11.34mm,P<0.01），LVEF更低（34.32%±6.79％ vs 38.02%±7.55％,P<005）。结论DCM伴发PVCs患者比无PVCs患者心功能分级更高，左心室功能更差，提示临床应足够重视PVCs的诊断和治疗，可改善患者心功能水平以及预后。 |
| 中文关键词:频发性室性期前收缩 扩张型心肌病 超敏C反应蛋白 心功能 |
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| The Influence of Frequent Ventricular Premature Contractions on the Inflammatory Status and Cardiac Function in Patients with Dilated Cardiomyopathy |
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| Abstract:ObjectiveTo investigate the influence of frequent ventricular premature contractions on the inflammatory status and cardiac function in patients with dilated cardiomyopathy (DCM). MethodsWe compared the differences of hs-CRP level,NYHA classes，NT-proBNP level，left ventricular end diastolic diameter(LVEDD) and left ventricular ejection fraction(LVEF) between DCM accompanied with PVCs group and non-accompanied with PVCs group.ResultsThere was no significant difference in hs-CRP level between DCM accompanied with PVCs group and non-accompanied with PVCs group(4.21±2.39mg/L vs 3.75±2.25mg/L,P>0.05).NYHA classes were higher（3.02±0.62 class vs 2.68±0.66 class，P<0.05）.The number of patients whose NT-proBNP concentration ≥ 1800pg/ml were more（105/128 vs 37/60，P<0.01）.LVEDD was strikingly greater（65.65±7.82mm vs 59.63±11.34mm,P<0.01）.LVEF was lower（34.32%±6.79％ vs 38.02%±7.55％,P<0.05）.ConclusionHeart failure is more serious and left ventricular function is worse in patients of dilated cardiomyopathy with PVCs than those without PVCs，which suggestes that adequate attention should be given to PVCs clinical diagnosis and treatment. |
| keywords:Frequent ventricular premature contractions Dilated cardiomyopathy High-sensitivity C-reactive protein Cardiac function |
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