| EGFR基因突变检测与肿瘤指标相关性研究 |
| 投稿时间：2010-11-16 修订日期：2010-12-01 点此下载全文 |
| 引用本文：徐琳,郑明峰,张稷,朱幸沨,陈若,陆荣国,吴波,陈静瑜.EGFR基因突变检测与肿瘤指标相关性研究[J].医学研究杂志,2011,40(8):79-81 |
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| 中文摘要:目的分析非小细胞肺癌患者（NSCLC）中表皮生长因子（EGFR）基因突变与相关肿瘤指标：癌胚抗原（CEA）、糖类抗原125（CA125）、糖类抗原199（CA199）之间的相关性。方法对笔者医院2010年1~10月间78例非小细胞肺癌患者术前进行肿瘤指标（CEA、CA125、CA199）检测，同时手术切除肿瘤标本进行EGFR基因检测，对所得结果进行统计分析。结果78例患者EGFR突变率为55.1％，其中16例患者发生了第19号外显子缺失突变，突变率为20.5％，27例患者发生了第21号外显子L858R点突变，突变率为34.6％。37例NSCLC患者的CEA表达阳性，占47.44％，均为腺癌患者。28例患者CA125表达阳性，占35.90%。11例患者CA199表达阳性，占14.1%。结论EGFR基因突变阳性与血清肿瘤指标CEA表达阳性具有统计学意义，而与CA125、CA199表达无统计学意义。因此，对不能进行外科手术治疗的晚期肺癌患者，同时无法获取满意组织标本进行EGFR基因检测时，若肿瘤指标CEA阳性时，可能具有更高的EGFR基因突变率。 |
| 中文关键词:非小细胞肺癌 EGFR基因突变 CEA |
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| CEAEGFR Mutations in Correlation with the Tumor Markers in NSCLC Patients |
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| Abstract:ObjectiveTo analyze the correlation between the epidermal growth factor (EGFR) gene mutations and tumor markers——carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125),carbohydrate antigen 199(CA199) in non-small cell lung cancer (NSCLC).MethodsThe tumor markers (CEA,CA125,CA199) were detected before surgery in 78 cases of non-small cell lung cancer patients in hospital from January 2010 to October 2010,while EGFR genetic examination from surgical tumor specimens was performed,and statistical analysis of results was carried out.ResultsIn 78 patients,EGFR mutation rate was 55.1%,and of these,16 patients had No.19 deletion mutation,with the mutation rate of 20.5%,while 27 patients had No.21 L858R point mutation,with the mutation rate of 34.6%.Thirty-seven patients had positive expression of CEA in patients with NSCLC,accounting for 47.44%,and all the pathology diagnosis were adenocarcinoma.Twenty-eight patients were positive for CA125 expression,accounting for 35.90%.CA199 expression was positive in 11 patients,accounting for 14.1%.ConclusionPositive EGFR mutation and increased serum level of tumor markers of CEA,CA125 has statistical significance.There wasn′t statistically significant in CA199 expression.Therefore,in patients with advanced lung cancer being unable to be surgically treated and having no satisfactory tissue samples to perform EGFR genetic exams,CEA-positive may suggest a higher rate of EGFR mutations. |
| keywords:Non-small cell lung cancer EGFR gene mutations CEA |
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