| 吲哚菁氯潴留率对食管曲张静脉破裂出血的预后评估 |
| 投稿时间：2010-12-12 修订日期：2010-12-25 点此下载全文 |
| 引用本文：李雅洁,金瑞放,黄智铭,吴建胜.吲哚菁氯潴留率对食管曲张静脉破裂出血的预后评估[J].医学研究杂志,2011,40(11):155-156 |
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| 中文摘要:目的分析吲哚菁氯潴留率（ICG-R15）与肝硬化食管胃底曲张静脉破裂出血患者预后的关系。方法应用吲哚菁氯排泄试验检测108例肝硬化食管胃底曲张静脉破裂出血患者，并根据ICG-R15分为3组，比较3组间1年内再出血率的差异。并用受试者工作特征曲线分析ICG-R15、终末期肝病模型（MELD）评分以及Child-Pugh评分预测肝硬化食管胃底曲张静脉破裂再出血的敏感度、特异度、约登指数及曲线下面积(AUROC)，分析各评分标准对再出血的预见能力。结果食管胃底静脉曲张破裂出血患者的再出血率随着ICG-R15的增高而增高，3组间有显著差异(P<0.05)。ICG-R15在判断再出血的敏感度最高达97.4%，特异度最高达75.0%，AUROC最大。结论ICG-R15有助于预测肝硬化食管胃底曲张静脉破裂出血患者的再出血率。 |
| 中文关键词:吲哚菁氯潴留率 食管静脉曲张破裂出血 MELD评分 受试者工作特征曲线 |
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| Retention Rate of Indocyanine Green for Predicting the Prognosis of Cirrhotic Patients with Esophageal Varices Bleeding |
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| Abstract:ObjectiveTo evaluate the re-bleeding rate in patients with cirrhosis esophageal varices bleeding using retention rate of indocyanine green at fifteen minutes(ICG-R15).MethodsA total of 108 patients were tested with ICG-R15.Based on the ICG-R15，all patients were divided into three groups. The difference of the re-bleeding rate in one year was compared among the three groups. And for assessing the value of predicting re-bleeding rate in cirrhotic patients with esophageal varices bleeding, the ICG-R15,MELD score and Child-Pugh score were calculated and evaluated by calculating receiver operator characteristic（ROC）curves,the sensitivity,the specificity,the Youden Index and the area under the AUROC curve. ResultsThe incidence of re-bleeding was significantly different among the three groups with ICG-R15 test (P<0.05). The ICG-R15 had sensitivity of 97.4%,specificity of 75.0% and the largest AUROC for predicting the incidence of re-bleeding in patients with cirrhosis esophageal varices bleeding. ConclusionThe ICG-R15 is a good parameter for predicting the prognosis of cirrhotic patients with esophageal varices bleeding． |
| keywords:Indocyanine green test Esophageal varices bleeding MELD score ROC curve |
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